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首页> 外文期刊>Infection and immunity >Early Local Cytokine Profiles in Strains of Mice with Different Outcomes from Chlamydial Genital Tract Infection
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Early Local Cytokine Profiles in Strains of Mice with Different Outcomes from Chlamydial Genital Tract Infection

机译：衣原体生殖道感染不同结果的小鼠菌株的早期局部细胞因子谱。

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In this study, we expand on the examination of genetically determined differences in host responses that correlate with clearance of Chlamydia trachomatis from the genital tract. We infected C57BL/6, BALB/c, and C3H/HeN mice with the mouse pneumonitis agent of C. trachomatis (MoPn). C57BL/6 mice had the shortest course of infection (22 days) and the lowest incidence of severe hydrosalpinx. BALB/c mice also had a short course of infection (25 days), but all developed hydrosalpinx. C3H/HeN mice had the longest course of infection (38 days), and all developed severe hydrosalpinx. Determination of local cytokine responses by enzyme-linked immunosorbent assay (ELISA) of genital tract secretions revealed that the levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) were significantly increased in the C57BL/6 and BALB/c strains compared to those in the C3H/HeN strain whereas the level of IL-6 was not different. The level of the neutrophil chemokine macrophage inflammatory protein 2 (MIP-2) was increased during the first week of infection in all three strains but was significantly higher in the BALB/c strain, the strain with the most rapid influx of neutrophils into the genital tract. Prolonged detection of MIP-2 in C3H/HeN mice was associated with a protracted presence of neutrophils in the genital tract. Early increases in the levels of the proinflammatory cytokines TNF-α and IL-1β are associated with earlier eradication of infection in the C57BL/6 and BALB/c strains than in the C3H/HeN strain. Increased levels of MIP-2 and neutrophils in BALB/c and C3H/HeN mice relative to C57BL/6 mice suggest that these responses may contribute to pathology.
机译：在这项研究中，我们扩展了对宿主反应的遗传学确定差异的检查，这些差异与沙眼衣原体从生殖道的清除相关。我们用 C的小鼠肺炎药感染了C57BL / 6，BALB / c和C3H / HeN小鼠。沙眼（MoPn）。 C57BL / 6小鼠的感染过程最短（22天），重度输卵管积水的发生率最低。 BALB / c小鼠的感染过程也很短（25天），但是所有小鼠都出现了输卵管积水。 C3H / HeN小鼠的感染过程最长（38天），并且全部发展为严重的输卵管积水。通过酶联免疫吸附法（ELISA）测定生殖道分泌物的局部细胞因子反应表明，促炎细胞因子肿瘤坏死因子α（TNF-α）和白细胞介素1β（IL-1β）的水平显着升高。 C57BL / 6和BALB / c菌株与C3H / HeN菌株相比，但IL-6的水平没有差异。在感染的第一周，中性粒细胞趋化因子巨噬细胞炎性蛋白2（MIP-2）的水平在所有三个菌株中均增加，但在BALB / c菌株中明显升高，BALB / c菌株是中性粒细胞流入生殖器最快的菌株道。 C3H / HeN小鼠中MIP-2的延长检测与生殖道中嗜中性粒细胞长期存在有关。与C3H / HeN菌株相比，C57BL / 6和BALB / c菌株中促炎细胞因子TNF-α和IL-1β的早期升高与感染的根除更早有关。相对于C57BL / 6小鼠，BALB / c和C3H / HeN小鼠中MIP-2和嗜中性粒细胞的水平升高表明，这些应答可能与病理有关。

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