Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis

Paola Salvatore; Caterina Pagliarulo; Roberta Colicchio; Patrizia Zecca; Giuseppina Cantalupo; Maurizio Tredici

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Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达

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Transposition plays a role in the epidemiology and pathogenesis ofNeisseria meningitidis. Insertion sequences are involved in reversible capsulation and insertional inactivation of virulence genes encoding outer membrane proteins. In this study, we have investigated and identified one way in which transposon IS1106 controls its own activity. We have characterized a naturally occurring protein (Tip) that inhibits the transposase. The inhibitor protein is a truncated version of the IS1106 transposase lacking the NH₂-terminal DNA binding sequence, and it regulates transposition by competing with the transposase for binding to the outside ends of IS1106, as shown by gel shift and in vitro transposition assays. IS1106Tip mRNA is variably expressed among serogroup B meningococcal clinical isolates, and it is absent in most collection strains belonging to hypervirulent lineages.

机译：转座在奈瑟菌脑膜炎的流行病学和发病机理中起作用。插入序列涉及编码外膜蛋白的毒力基因的可逆包封和插入失活。在这项研究中，我们调查并确定了转座子IS 1106 控制其自身活性的一种方式。我们已经表征了抑制转座酶的天然蛋白质（Tip）。抑制剂蛋白是缺少NH _{2 末端DNA结合序列的IS 1106 转座酶的截短形式，它通过与转座酶竞争与外界的结合来调节转座。 IS 1106 的末端，如凝胶电泳和体外转座分析所示。 IS 1106 Tip mRNA在B群脑膜炎球菌临床分离株中可变表达，并且在大多数属于高毒力谱系的菌株中不存在。} 展开▼

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《Infection and immunity》 |2001年第12期|共12页

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Paola Salvatore; Caterina Pagliarulo; Roberta Colicchio; Patrizia Zecca; Giuseppina Cantalupo; Maurizio Tredici;
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中图分类医学免疫学;

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1. Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis [J] . Paola Salvatore, Caterina Pagliarulo, Roberta Colicchio, Infection and immunity . 2001,第12期

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达

2. Endothelial Adhesion Molecule Expression and Its Inhibition by Recombinant Bactericidal/Permeability-Increasing Protein Are Influenced by the Capsulation and Lipooligosaccharide Structure ofNeisseria meningitidis [J] . Garth L. J. Dixon, Robert S. Heyderman, Karolena Kotovicz, Infection and immunity . 1999,第11期

机译：脑膜炎奈瑟氏球菌的包封和脂寡糖结构影响内皮粘附分子的表达及其对重组杀菌/通透性增强蛋白的抑制作用

3. Identification and characterization of Bamboo mosaic virus isolates from a naturally occurring coinfection in Bambusa xiashanensis [J] . Lin Wenwu, Wang Lu, Yan Wenkai, Archives of virology . 2017,第5期

机译：Bambusa XiaShanensis天然繁殖竹马赛克病毒分离物的鉴定与表征

4. Affinity Screening of Purified GPCRs on the Automated Ligand Identification System (ALIS): Protein Expression, Characterization, and Screening Results for CXCR4 [C] . Charles E. Whitehurst, Zhiping Yao, Denise Murphy, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：在自动配体鉴定系统（ALIS）上的纯化GPCR的亲和筛选：CXCR4的蛋白质表达，表征和筛选结果

5. Using a naturally occurring viral protein and a small molecule compound to inhibit B cell immunoglobulin class-switch DNA recombination. [D] . Lam, Tonika. 2014

机译：使用天然存在的病毒蛋白和小分子化合物抑制B细胞免疫球蛋白类别转换DNA重组。

6. Identification Characterization and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates of Neisseria meningitidis [O] . Paola Salvatore, Caterina Pagliarulo, Roberta Colicchio, 2001

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定表征和可变表达

7. Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates of Neisseria meningitidis [O] . Salvatore, Paola, Pagliarulo, Caterina, Colicchio, Roberta, 2001

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达

8. Characterization of Two C. Elegans Homologuses of Oncogenic Inhibitor of Apoptosis Proteins (IAPs) and Identification of Interacting Genes. [R] . Fraser, A. G., Ahringer, J. 2002

机译：细胞凋亡蛋白（Iaps）致癌抑制剂两种线虫同系物的表征及相互作用基因的鉴定。

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2. 含重组菌毛蛋白的抗淋病奈瑟氏球茵或脑膜炎奈瑟氏球菌的疫苗 [P] . 中国专利： CN1298446A . 2001-06-06

3. Expression methods of non-naturally occurring amino acid protein embedded [P] . 外国专利： JPWO2004039989A1 . 2006-03-02

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4. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors [P] . 外国专利： US2003119002A1 . 2003-06-26

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5. Identification and comparison of proteinamp;mdash;protein interactions that occur in populations and identification of inhibitors of these interactors [P] . 外国专利： US6410239B1 . 2002-06-25

机译：鉴定和比较种群中发生的蛋白质-蛋白质相互作用以及这些相互作用因子的抑制剂

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Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis

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