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Identification Characterization and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates of Neisseria meningitidis

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定表征和可变表达

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摘要

Transposition plays a role in the epidemiology and pathogenesis of Neisseria meningitidis. Insertion sequences are involved in reversible capsulation and insertional inactivation of virulence genes encoding outer membrane proteins. In this study, we have investigated and identified one way in which transposon IS1106 controls its own activity. We have characterized a naturally occurring protein (Tip) that inhibits the transposase. The inhibitor protein is a truncated version of the IS1106 transposase lacking the NH2-terminal DNA binding sequence, and it regulates transposition by competing with the transposase for binding to the outside ends of IS1106, as shown by gel shift and in vitro transposition assays. IS1106Tip mRNA is variably expressed among serogroup B meningococcal clinical isolates, and it is absent in most collection strains belonging to hypervirulent lineages.

机译：转座在脑膜炎奈瑟氏球菌的流行病学和发病机理中起作用。插入序列涉及可逆的封装和编码外膜蛋白的毒力基因的插入失活。在这项研究中，我们已经研究并确定了转座子IS1106控制其自身活性的一种方式。我们已经表征了抑制转座酶的天然蛋白质（Tip）。抑制剂蛋白是IS1106转座酶的截短形式，缺少NH2末端DNA结合序列，并且通过与转座酶竞争结合IS1106的外端来调节转座，如凝胶迁移和体外转座试验所示。在血清群B脑膜炎球菌临床分离株中，IS1106Tip mRNA的表达是可变的，而在大多数属于高毒力谱系的菌株中却不存在。

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期刊名称 Infection and Immunity
作者
Paola Salvatore; Caterina Pagliarulo; Roberta Colicchio; Patrizia Zecca; Giuseppina Cantalupo; Maurizio Tredici; Alfredo Lavitola; Cecilia Bucci; Carmelo B. Bruni; Pietro Alifano;
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年(卷),期 2001(69),12
年度 2001
页码 7425–7436
总页数 12
原文格式 PDF
正文语种
中图分类免疫学;病毒传染病;
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专利

1. Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis [J] . Paola Salvatore, Caterina Pagliarulo, Roberta Colicchio, Infection and immunity . 2001,第12期

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达
2. Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates ofNeisseria meningitidis [J] . Paola Salvatore, Caterina Pagliarulo, Roberta Colicchio, Infection and immunity . 2001,第12期

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达
3. Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures [J] . Jaekel Anne, Plested Joyce S, Hoe JClaire, Vaccine . 2008,第51期

机译：脑膜炎奈瑟氏球菌内脂脂质表位的天然人血清抗体可预防由表现出同源内核结构的分离株引起的浸润性脑膜炎球菌病
4. Affinity Screening of Purified GPCRs on the Automated Ligand Identification System (ALIS): Protein Expression, Characterization, and Screening Results for CXCR4 [C] . Charles E. Whitehurst, Zhiping Yao, Denise Murphy, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：在自动配体鉴定系统（ALIS）上的纯化GPCR的亲和筛选：CXCR4的蛋白质表达，表征和筛选结果
5. Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis. [D] . Ingrey, Keely. 2010

机译：脑膜炎奈瑟氏球菌中假定的血红素ABC转运蛋白的鉴定和分子表征。
6. Identification and Characterization of pptA: a Gene Involved in the Phase-Variable Expression of Phosphorylcholine on Pili of Neisseria meningitidis [O] . Matthew J. Warren, Michael P. Jennings 2003

机译：pptA的鉴定和表征：一个基因在脑膜炎奈瑟氏菌的菌毛上磷酸胆碱的相变表达
7. Identification, Characterization, and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates of Neisseria meningitidis [O] . Salvatore, Paola, Pagliarulo, Caterina, Colicchio, Roberta, 2001

机译：脑膜炎奈瑟氏球菌临床分离株中IS1106转座酶的天然抑制剂蛋白的鉴定，表征和可变表达
8. Characterization of Two C. Elegans Homologuses of Oncogenic Inhibitor of Apoptosis Proteins (IAPs) and Identification of Interacting Genes. [R] . Fraser, A. G., Ahringer, J. 2002

机译：细胞凋亡蛋白（Iaps）致癌抑制剂两种线虫同系物的表征及相互作用基因的鉴定。

Identification Characterization and Variable Expression of a Naturally Occurring Inhibitor Protein of IS1106 Transposase in Clinical Isolates of Neisseria meningitidis

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