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首页> 外文期刊>Infection and immunity >Establishment of a Persistent Escherichia coli Reservoir during the Acute Phase of a Bladder Infection
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Establishment of a Persistent Escherichia coli Reservoir during the Acute Phase of a Bladder Infection

机译：在膀胱感染急性期建立一个持久性大肠杆菌水库

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The vast majority of urinary tract infections are caused by strains of uropathogenic Escherichia coli that encode filamentous adhesive organelles called type 1 pili. These structures mediate both bacterial attachment to and invasion of bladder epithelial cells. However, the mechanism by which type 1 pilus-mediated bacterial invasion contributes to the pathogenesis of a urinary tract infection is unknown. Here we show that type 1-piliated uropathogens can invade the superficial epithelial cells that line the lumenal surface of the bladder and subsequently replicate, forming massive foci of intracellular E. coli termed bacterial factories. In response to infection, superficial bladder cells exfoliate and are removed with the flow of urine. To avoid clearance by exfoliation, intracellular uropathogens can reemerge and eventually establish a persistent, quiescent bacterial reservoir within the bladder mucosa that may serve as a source for recurrent acute infections. These observations suggest that urinary tract infections are more chronic and invasive than generally assumed.
机译：绝大多数尿路感染是由泌尿道致病性大肠埃希氏菌菌株引起的，该菌株编码称为1型菌毛的丝状粘附细胞器。这些结构介导细菌附着于膀胱上皮细胞并侵入膀胱上皮细胞。但是，尚不清楚1型菌毛介导的细菌入侵导致尿路感染的发病机理的机制。在这里，我们显示类型为1的尿路致病菌可以侵入排在膀胱腔表面的浅表上皮细胞，然后复制，形成细胞内Eem的大量病灶。大肠杆菌称为细菌工厂。响应感染，浅表膀胱细胞脱落并随尿流清除。为了避免脱落引起的清除，细胞内尿路病原体可以重新出现，并最终在膀胱粘膜内建立持久的，静止的细菌库，这可能是复发性急性感染的来源。这些观察结果表明，泌尿道感染比一般假定的更为慢性和侵袭性。

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