Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils

Riana Cockeran; Helen C. Steel; Timothy J. Mitchell; Charles Feldman; Ronald Anderson

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Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils

机译：肺炎球菌溶血素增强人嗜中性粒细胞产生前列腺素E2和白三烯B4的能力。

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Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E₂ and leukotriene B₄ by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

机译：暴露于肺炎球菌溶血素（8.37和41.75 ng / ml）导致静息和激活化学作用的人前列腺素E _{2 和白三烯B _{4 的生成均依赖钙中性粒细胞体外。肺炎球菌溶血素与嗜中性粒细胞的这些相互作用可能导致肺炎球菌感染期间炎症反应失调。}}

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《Infection and immunity》 |2001年第5期|共3页
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Riana Cockeran; Helen C. Steel; Timothy J. Mitchell; Charles Feldman; Ronald Anderson;
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1. Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production [J] . FischerC.D., DuquetteS.C., RenauxB.S., Antimicrobial agents and chemotherapy. . 2014,第8期

机译：图拉霉素通过抑制磷脂酶和改变白三烯B4，前列腺素E2和脂蛋白A4的产生而在牛中性粒细胞中发挥前效作用。
2. Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic‐free calcium in human neutrophils [J] . Dayer Jean-Michel, Lew P.Daniel, Pozzan Tullio, FEBS Letters . 1984,第1期

机译：白三烯B4，前列腺素E2和花生四烯酸对人中性粒细胞中无钙质钙的影响
3. Differential production of leukotriene B4 or prostaglandin E2 by WKYMVm or serum amyloid A via formyl peptide receptor-like 1. [J] . Lee HY, Jo SH, Lee C, Biochemical Pharmacology . 2006,第7期

机译：WKYMVm或血清淀粉样蛋白A通过甲酰肽受体样1产生白三烯B4或前列腺素E2的差异性产生。
4. Comparison of Inhibitory Effects of Nine Flavonoids on Prostaglandin E2 Production and COX-2 Expression in LPS-Stimulated RAW264.7 Macrophages [C] . Xu Yirong, Wang Changlu, Wu Longyan, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：比较九种黄酮类化合物对LPS刺激的RAW264.7巨噬细胞中前列腺素E2产生和COX-2表达的抑制作用。
5. Effects of prostaglandin E2 on the production of chemokines by dendritic cells. [D] . Jing, Huie. 2005

机译：前列腺素E2对树突状细胞产生趋化因子的影响。
6. Note: Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils [O] . Riana Cockeran, Helen C. Steel, Timothy J. Mitchell, 2001

机译：注意：肺炎球菌溶血素增强人嗜中性粒细胞产生前列腺素E2和白三烯B4的能力。
7. Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils [O] . Cockeran, Riana, Steel, Helen C., Mitchell, Timothy J., 2001

机译：肺炎球菌溶血素增强人嗜中性粒细胞产生前列腺素E2和白三烯B4的能力。
8. Lavage of Leukotriene B4 Induces Lung Generation of Tumor Necrosis Factor-A and Neutrophil Diapedesis [R] . Goldman, G. , Welbourn, R. , Kobzik, L. , 1991

机译：白三烯B4的灌洗诱导肿瘤坏死因子-a和中性粒细胞的血液生成

Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils

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