Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic‐free calcium in human neutrophils

Dayer Jean-Michel; Lew P.Daniel; Pozzan Tullio; Wollheim Claes B.

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Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic‐free calcium in human neutrophils

机译：白三烯B4，前列腺素E2和花生四烯酸对人中性粒细胞中无钙质钙的影响

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>Changes in cytosolic free calcium [Ca2+]_i and release of beta-glucuronidase in response to leukotriene B₄ (LTB₄) were measured in intact neutrophils loaded with the fluorescent Ca2+ indicator, quin 2. LTB₄ (10−10 M or higher) caused a rapid rise in [Ca2+]_i due to influx from the extracellular medium and release from intracellular pools as well as enzyme release. PGE₂ (3 μM) did not alter [Ca2+]_i whereas arachidonic acid (10 μM) raised [Ca2+]_i. Pretreatment of cells with the chemotactic peptide FMLP inhibited the subsequent rise of [Ca2+]_i induced by LTB₄. Since chemotactic peptides activate the lipoxygenase pathway of arachidonic acid metabolism, it may be speculated that endogenous LTB₄ generation is involved in neutrophil activation.

机译：>对白三烯B _{4 的响应（LTB <，细胞内游离钙[Ca 2 + ] _{i 的变化和β-葡萄糖醛酸苷酶的释放在装有荧光Ca 2 + 指示剂quin 2的完整嗜中性白细胞中测量了sub> 4 ）。LTB _{4 （10 −10 M或更高）导致[Ca 2 + ] _{i 迅速上升，这是由于从细胞外培养基中流入并从细胞内池中释放以及酶释放。 PGE _{2 （3μM）没有改变[Ca 2 + ] _{i ，而花生四烯酸（10μM）升高了[Ca 2 + ] _{i 。用趋化肽FMLP预处理细胞可抑制LTB _{4 诱导的[Ca 2 + ] _{i 随后的升高。由于趋化肽激活花生四烯酸代谢的脂氧合酶途径，因此可以推测内源性LTB _{4 的产生与嗜中性粒细胞的激活有关。}}}}}}}}}}

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《FEBS Letters》 |1984年第1期|共页
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Dayer Jean-Michel; Lew P.Daniel; Pozzan Tullio; Wollheim Claes B.;
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1. Pneumolysin Potentiates Production of Prostaglandin E2 and Leukotriene B4 by Human Neutrophils [J] . Riana Cockeran, Helen C. Steel, Timothy J. Mitchell, Infection and immunity . 2001,第5期

机译：肺炎球菌溶血素增强人嗜中性粒细胞产生前列腺素E2和白三烯B4的能力。
2. Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement. [J] . Grenier S, Flamand N, Pelletier J, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2003,第4期

机译：花生四烯酸激活人嗜中性粒细胞中的磷脂酶D;内源性白三烯B4的基本作用和腺苷A2A受体参与的抑制作用。
3. Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement [J] . Julie Pelletier, Nicolas Flamand, Paul H. Naccache, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2003,第4期

机译：花生四烯酸激活人嗜中性粒细胞中的磷脂酶D;内源性白三烯B4的重要作用以及腺苷A2A受体参与的抑制作用
4. Metabolism and protein adduction of a cyclooxygenase-2/15-prostaglandin dehydrogenase derived product from arachidonic acid. [C] . Nathaniel W. Snyder, Alejandro A. Pacheco, Xiaojing Liu, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

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6. Leukotriene B4 and prostaglandin E2 mediate the inflammatory response of rabbit skin to intradermal arachidonic acid. [O] . D. M. Aked, S. J. Foster 1987

机译：白三烯B4和前列腺素E2介导兔皮肤对皮内花生四烯酸的炎症反应。
7. Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic-free calcium in human neutrophils [O] . Lew P.Daniel, Dayer Jean-Michel, Wollheim Claes B., 1984

机译：白三烯B4，前列腺素E2和花生四烯酸对人中性粒细胞中游离钙的影响
8. Arachidonic Acid and Prostaglandins Enhance Potassium-Stimulated Calcium InFluxinto Rat Brain Synaptosomes [R] . Kandasamy, S. B., Hunt, W. A. 1990

机译：花生四烯酸和前列腺素增强钾刺激的钙在大鼠脑突触体中的作用

Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic‐free calcium in human neutrophils

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