Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection

Annie George-Chandy; Nathalie Mielcarek; Inger Nordstr?m; Jan Holmgren; Kristina Eriksson

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Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection

机译：百日咳博德特氏菌脉冲自体或异源树突状细胞接种疫苗可诱导粘膜抗体体内应答并预防感染

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This study demonstrates for the first time that vaccination with either autologous or heterologous dendritic cells (DC) pulsed with specific antigen induces protective immune responses against noninvasive bacteria, namely Bordetella pertussis. The DC-mediated protection is associated with strong B. pertussis-specific immunoglobulin G (IgG) and IgA responses in the lung.

机译：这项研究首次证明，接种带有特定抗原的自体或异源树突状细胞（DC）疫苗可诱导针对非侵入性细菌百日咳博德特氏菌的保护性免疫应答。 DC介导的保护与强力 B相关。百日咳特异性免疫球蛋白G（IgA）和肺中的IgA反应。 展开▼

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《Infection and immunity》 |2001年第6期|共5页

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Annie George-Chandy; Nathalie Mielcarek; Inger Nordstr?m; Jan Holmgren; Kristina Eriksson;
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中图分类医学免疫学;

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专利

1. An agonist antibody specific for CD40 induces dendritic cell maturation and promotes autologous anti-tumour T-cell responses in an in vitro mixed autologous tumour cell/lymph node cell model. [J] . Hunter TB, Alsarraj M, Gladue RP, Scandinavian journal of immunology. . 2007,第5期

机译：在体外混合的自体肿瘤细胞/淋巴结细胞模型中，对CD40特异的激动剂抗体可诱导树突状细胞成熟并促进自体抗肿瘤T细胞反应。

2. Vaccination with autologous tumor-loaded dendritic cells induces clinical and immunologic responses in indolent B-cell lymphoma patients with relapsed and measurable disease: a pilot study. [J] . Di-Nicola M, Zappasodi R, Carlo-Stella C, Blood: The Journal of the American Society of Hematology . 2009,第1期

机译：在患有复发且可测量疾病的惰性B细胞淋巴瘤患者中，用自体肿瘤加载的树突状细胞接种疫苗可诱导临床和免疫应答：一项先导研究。

3. Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates [J] . Warfel J.M., Merkel T.J. Mucosal immunology . 2013,第4期

机译：百日咳博德特氏菌感染在非人类灵长类动物中诱导粘膜IL-17反应和长寿命的Th17和Th1免疫记忆细胞

4. INFLUENCE OF MATERNAL ANTIBODIES INDUCED BY SOW VACCINATION ON IMMUNE RESPONSE TO MYCOPLASMA HYOPNEUMONIAE INFECTION IN VACCINATED AND NON-VACCINATED PIGS [C] . SUSANNE LEHNER, DIANA MEEMKEN, HEIKO NATHUES, Congress of the International Pig Veterinary Society . 2008

机译：母猪疫苗诱导诱导母体抗体对接种疫苗和非接种疫苗猪支原体吞噬作用感染的影响

5. Setting the Stage for a Potential Varicella-Zoster Virus (VZV)-Based HIV Vaccine: Characterization of the Mucosal Immune Response Induced by VZV Vaccination in Humans [D] . Perciani, Catia Taniela. 2019

机译：为潜在的水痘 - 带状疱疹病毒（VZV）的阶段为基础的HIV疫苗：在人类中vzV疫苗接种诱导的粘膜免疫应答的表征

6. Note: Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection [O] . Annie George-Chandy, Nathalie Mielcarek, Inger Nordström, 2001

机译：注意：用百日咳博德特氏菌脉冲的自体或异源树突状细胞接种疫苗可诱导粘膜抗体体内反应并防止感染

7. Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection [O] . George-Chandy, Annie, Mielcarek, Nathalie, Nordström, Inger, 2001

机译：百日咳博德特氏菌脉冲自体或异源树突状细胞接种疫苗可诱导粘膜抗体体内应答并预防感染

1. 027 免疫百日咳杆菌脉冲自体或异体树突状细胞能诱导体内粘膜抗体应答和预防感染 [J] . . 国际生物制品学杂志 . 2002,第002期

2. 银川地区持续性咳嗽儿童百日咳博德特菌感染临床调查 [J] . 陈彦香 ,王传清 ,李乐 . 临床儿科杂志 . 2012,第009期

3. 乳腺癌细胞抗原负载的自体树突状细胞体内诱导特异性T细胞应答 [J] . 朱玉兰 ,钱科卿 ,秦建伟 . 中华实验外科杂志 . 2010,第006期

4. 090鼻内接种蔗糖乙酸异丁酸酯释放系统能诱导对马链球菌SeMF3特异性粘膜和全身抗体应答 [J] . . 国际生物制品学杂志 . 2001,第004期

5. 成人百日咳鲍德特菌感染的临床特点及菌株体外耐药性分析 [J] . 马富艳 ,华春珍 ,谢永平 . 中国抗生素杂志 . 2021,第009期

6. 博德特氏菌产透明质酸初步研究 [A] . 周茜 . 2009

1. 百日咳博德特氏菌和副百日咳博德特氏菌的特异性检测用引物探针组合和试剂盒 [P] . 中国专利： CN102634596B . 2016.08.03

2. 百日咳博德特氏菌和副百日咳博德特氏菌的特异性检测用引物探针组合和试剂盒 [P] . 中国专利： CN102634596A . 2012-08-15

3. Processes for releasing one or more biologically active polypeptides, and one or more antigens, to regulate the functions of survival, growth, differentiation, effector or susceptibility to infection of cells or tissues, to reinforce an immune response against tumor cells or a colonized infection a distant or adjacent mucosal surface or tissue, to modulate the type of immune response (antibody versus cell-mediated) against a pathogenic infectious agent, to induce apoptosis in cells [P] . 外国专利： BR9610929A . 1999-12-21

机译：释放一种或多种生物活性多肽和一种或多种抗原以调节细胞或组织感染的存活，生长，分化，效应子或易感性功能，增强针对肿瘤细胞或定植感染的免疫应答的方法远处或邻近的粘膜表面或组织，以调节针对病原性传染原的免疫应答类型（抗体对细胞介导），诱导细胞凋亡

4. How to Induce Antibody Responses to Autologous Proteins Using Heterologous T-Cell Epitopes [P] . 外国专利： KR100308444B1 . 2001-11-30

机译：如何使用异源T细胞表位诱导对自体蛋白质的抗体反应

5. vaccine, methods for inducing an immune response against an hbv antigen, for protecting a subject from hbv infection, for protecting the subject who was diagnosed with an hbv infection, for inducing an immune response against an hbv antigen, for protecting a individual from hbv infection, to protect an individual who was diagnosed with hbv infection, to protect an individual from hbv infection, to protect an individual who was diagnosed with hbv infection, to protect a subject from hbv infection, and to protect the subject who was diagnosed with an infection with hbv, nucleic acid molecule, and protein [P] . 外国专利： BR112015005987A2 . 2017-08-08

机译：疫苗，诱导针对hbv抗原的免疫反应，保护受试者免受hbv感染，保护被诊断患有hbv感染的受试者，诱导针对hbv抗原的免疫反应，保护个体免受hbv感染的方法，保护被诊断出患有乙型肝炎病毒感染的个体，保护个体免受乙型肝炎病毒感染，保护被诊断为乙型肝炎病毒感染的个体，保护个体免受乙型肝炎病毒感染以及保护被诊断出患有乙型肝炎病毒感染的个体与HBV，核酸分子和蛋白质

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Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection

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