...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury.
【24h】

Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury.

机译：腔内细菌细胞壁聚合物对急性结肠损伤大鼠的全身吸收和肠道炎症作用。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The systemic uptake and local intestinal inflammatory potential of luminal bacterial cell wall polymers in rats with normal and acutely inflamed colons were measured. Rats were injected intracecally with either 125I-labeled group A streptococcal peptidoglycan-polysaccharide complexes or equal amounts of Na125I, after either nonspecific colonic injury with 4% acetic acid or injection with buffer. The colons of rats injected with peptidoglycan-polysaccharide had higher inflammatory scores than Na125I-injected rats, a greater incidence of mucosal ulceration and transmural inflammation after acetic acid injury, and an increased frequency of focal accumulations of inflammatory cells in the lamina propria and submucosa after buffer injection. Radioactivity in the liver, spleen, and mesenteric lymph nodes was higher in the colon-injured rats that received peptidoglycan-polysaccharide 48 h before tissue collection than in the noninjured rats (P less than 0.002). Group A streptococcal polysaccharide antigen concentration within the liver, spleen, and mesenteric lymph nodes, measured by enzyme-linked immunosorbent assay, was significantly higher in the colon-injured rats that received cell wall polymers than in noninjured rats. These results indicate that luminal bacterial cell wall polymers with well-described inflammatory and immunoregulatory potential can cross injured colonic epithelia and are capable of initiating and potentiating intestinal inflammation.
机译：测量了正常和急性发炎的结肠大鼠腔内细菌细胞壁聚合物的全身吸收和局部肠道炎症潜能。在用4％乙酸进行非特异性结肠损伤或用缓冲液注射后，向大鼠脑内注射125I标记的A组链球菌肽聚糖-多糖复合物或等量的Na125I。注射肽聚糖多糖的大鼠结肠炎性评分高于注射Na125I的大鼠，乙酸损伤后黏膜溃疡发生率和透壁炎症发生率更高，且黏膜固有层和黏膜下层炎性细胞局灶性聚集的频率增加缓冲液注入。在收集组织前48小时接受肽聚糖多糖的结肠损伤大鼠中，肝脏，脾脏和肠系膜淋巴结的放射活性高于未损伤大鼠（P小于0.002）。通过酶联免疫吸附测定法测得的肝，脾和肠系膜淋巴结内的A组链球菌多糖抗原浓度在接受细胞壁聚合物的结肠损伤大鼠中明显高于未损伤大鼠。这些结果表明，具有充分描述的炎症和免疫调节潜能的腔内细菌细胞壁聚合物可以穿越受损的结肠上皮，并且能够引发和增强肠道炎症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号