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首页> 外文期刊>Infection and immunity >Early events in initiation of alternative complement pathway activation by the capsule of Cryptococcus neoformans.
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Early events in initiation of alternative complement pathway activation by the capsule of Cryptococcus neoformans.

机译：新型隐球菌荚膜启动替代补体途径激活的早期事件。

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The capsule of Cryptococcus neoformans is a powerful activator of the alternative complement pathway. This study examined the manner in which the cryptococcal capsule influences initiation of and early events in complement activation by C. neoformans. These studies examined the effects of the classical and alternative pathways on the kinetics and early sites for deposition of C3 fragments on encapsulated cryptococci, nonencapsulated cryptococci, and zymosan. The results showed that nonencapsulated cryptococci and zymosan are qualitatively and quantitatively similar in the manner in which they initiate complement activation. Both utilize the classical and alternative pathways. Initiation via the classical pathway occurs suddenly and simultaneously at sites distributed over the entire cell surface. Initiation of the alternative pathway by zymosan and nonencapsulated cryptococci is characterized by a lag of 6 to 8 min before appreciable amounts of C3 accumulate on the cells. Alternative pathway initiation by zymosan and nonencapsulated cryptococci occurs at a limited number of focal initiation sites that expand with alternative pathway amplification to cover the cell surface. Presence of the cryptococcal capsule blocks classical pathway initiation, which would normally occur at the cryptococcal cell wall, and produces an initiation that is dependent solely on the alternative pathway. Initiation of the alternative pathway by the cryptococcal capsule is characterized by a lag in C3 accumulation and the appearance of a limited number of focal initiation sites which resemble those observed when the alternative pathway is activated by zymosan and nonencapsulated cryptococci.
机译：新型隐球菌的胶囊是替代补体途径的强大激活剂。这项研究检查了隐球菌胶囊影响新孢梭菌补体激活的开始和早期事件的方式。这些研究检查了经典途径和替代途径对C3片段在包囊隐球菌，非包囊隐球菌和酵母聚糖上沉积的动力学和早期位点的影响。结果表明，未包囊的隐球菌和酵母聚糖在定性和定量上以它们启动补体激活的方式相似。两者都利用经典途径和替代途径。通过经典途径的引发突然并同时发生在分布于整个细胞表面的部位。由酵母聚糖和未包囊的隐球菌引发的替代途径的特征是在细胞上积累大量C3之前需要6至8分钟的延迟。由酵母聚糖和未包囊的隐球菌引起的替代途径起始发生在有限数量的焦点起始位点上，这些位点随着替代途径扩增而扩展以覆盖细胞表面。隐球菌胶囊的存在阻止了通常在隐球菌细胞壁上发生的经典途径的起始，并产生了仅依赖于替代途径的起始。隐球菌荚膜引发的替代途径的特征在于C3积累的滞后和有限数量的局灶性起始位点的出现，其与当酵母聚糖和未包囊的隐球菌激活替代途径时观察到的相似。

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