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首页> 外文期刊>Infection and immunity >Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan.
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Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan.

机译:来自荚膜组织胞浆的无毒变体的细胞壁缺乏α-(1,3)-葡聚糖。

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Cell wall composition of isogenic virulent-avirulent strain pairs of Histoplasma capsulatum varied markedly with respect to alpha-(1,3)-glucan content. When yeast cell walls were fractionated by standard techniques, the avirulent strains contained up to 1,000-fold less alpha-(1,3)-glucan than did their virulent parents. No alpha-(1,3)-glucan could be detected on the surface of the avirulent strain yeast cells if we used a mouse monoclonal antibody that recognized this polymer. A similar relationship between virulence and alpha-(1,3)-glucan has been described for Paracoccidioides brasiliensis. alpha-(1,3)-Glucan is also found in several other pathogenic fungi and may thus be an important common virulence determinant.
机译:荚膜组织胞浆的等基因有毒无毒菌株对的细胞壁组成在α-(1,3)-葡聚糖含量方面有显着差异。当通过标准技术对酵母细胞壁进行分级分离时,无毒力菌株所含的α-(1,3)-葡聚糖含量要比其有毒力的亲本低1000倍。如果我们使用能识别这种聚合物的小鼠单克隆抗体,则在无毒力的菌株酵母细胞表面上将无法检测到α-(1,3)-葡聚糖。对于巴西副球菌已经描述了毒性和α-(1,3)-葡聚糖之间的相似关系。 α-(1,3)-葡聚糖还存在于其他几种致病真菌中,因此可能是重要的常见毒力决定因素。

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