In vitro killing of Ehrlichia risticii by activated and immune mouse peritoneal macrophages.

N M Williams; P J Timoney

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In vitro killing of Ehrlichia risticii by activated and immune mouse peritoneal macrophages.

机译：活化的和免疫的小鼠腹膜巨噬细胞在体外杀死埃希氏毛虫。

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Normal resident murine peritoneal macrophages inoculated in vitro with Ehrlichia risticii readily phagocytized the organism but were unable to suppress ehrlichial replication as determined by indirect fluorescent-antibody staining of the inoculated cells. In contrast, macrophages from Corynebacterium parvum-inoculated and E. risticii-recovered mice rapidly eliminated the ehrlichiae. Macrophages from E. risticii-recovered mice were as effective as the C. parvum-activated cells in phagocytizing and eliminating the organism. Opsonization of E. risticii with homologous antiserum prior to inoculation of macrophage cultures resulted in enhancement of phagocytosis and greater suppression of E. risticii replication in all macrophage groups. These findings indicate that the pathogenesis of E. risticii infection centers on the ability of the organism to enter and replicate within the macrophage with avoidance of macrophage antimicrobial effects. An immune response results in macrophage activation with enhancement of the macrophage's ability to eliminate E. risticii. Opsonization of E. risticii with anti-E. risticii serum renders E. risticii more susceptible to macrophage destruction.

机译：体外用埃里希氏菌接种的正常鼠腹膜巨噬细胞很容易吞噬该生物，但不能通过接种细胞的间接荧光抗体染色确定抑制大肠杆菌的复制。相比之下，来自小棒杆菌接种的和重组大肠杆菌的小鼠的巨噬细胞迅速消除了大肠杆菌。在捕食和消灭该病原体中，来自大肠杆菌的小鼠的巨噬细胞与细小隐孢子虫激活的细胞一样有效。在接种巨噬细胞培养物之前，用同源抗血清对埃希氏大肠杆菌进行调理，可增强吞噬作用并在所有巨噬细胞组中更大程度地抑制埃希氏大肠杆菌的复制。这些发现表明，埃希氏大肠杆菌感染的发病机理集中在生物体进入巨噬细胞并在巨噬细胞内复制的能力，而避免了巨噬细胞的抗菌作用。免疫应答导致巨噬细胞活化，同时增强了巨噬细胞消除大肠杆菌的能力。 E. risticii与抗E的调理作用。 Risticii血清使E. risticii更容易受到巨噬细胞破坏。

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《Infection and immunity》 |1993年第3期|共7页
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N M Williams; P J Timoney;
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中图分类医学免疫学;
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6. In vitro killing of Ehrlichia risticii by activated and immune mouse peritoneal macrophages. [O] . N M Williams, P J Timoney 1993

机译：活化的和免疫的小鼠腹膜巨噬细胞在体外杀死埃希氏毛虫。
7. In vitro killing of Ehrlichia risticii by activated and immune mouse peritoneal macrophages [O] . N M Williams, P J Timoney 1993

机译：通过活化和免疫小鼠腹膜巨噬细胞体外杀死Ehrlichia Risticii
8. Substrate Utilization by 'Ehrlichia sennetsu' and 'Ehrlichia risticii' Separated from Host Constituents by Renografin Gradient Centrifugation [R] . Weiss, E., Dasch, G. A., Kang, Y. H., 1988

机译：通过Renografin梯度离心从'Ehrlichia sennetsu'和'Ehrlichia risticii'中分离宿主成分的底物利用

In vitro killing of Ehrlichia risticii by activated and immune mouse peritoneal macrophages.

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