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Expression of Hemin Receptor Molecule ChuA Is Influenced by RfaH in Uropathogenic Escherichia coliStrain 536

机译:尿毒症性大肠杆菌菌株536中的RfaH影响着Hemin受体分子ChuA的表达。

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The outer membrane protein ChuA responsible for hemin utilization has been recently identified in several pathogenic Escherichia coli strains. We report that the regulatory protein RfaH influences ChuA expression in the uropathogenic E. colistrain 536. In an rfaH mutant, the chuAtranscript as well as the ChuA protein levels were significantly decreased in comparison with those in the wild-type strain. Within thechuA gene, a consensus motif known as the JUMPStart (just upstream of many polysaccharide associated gene starts) sequence was found, which is shared by RfaH-affected operons. Furthermore, the presence of two different subclasses of thechuA determinant and their distribution in E. coli pathogroups are described.
机译:最近在几种致病性大肠杆菌菌株中发现了负责血红素利用的外膜蛋白ChuA。我们报告说,调节蛋白RfaH影响尿毒症 E中的ChuA表达。大肠杆菌菌株536.在 rfaH 突变体中,与野生型菌株相比, chuA 转录本和ChuA蛋白水平显着降低。在 chuA 基因中,发现了一个共有基序,称为JUMPStart(恰好在许多与多糖相关的基因起始位点的上游)序列,该序列由受RfaH影响的操纵子共有。此外, chuA 行列式的两个不同子类的存在及其在 E中的分布。描述了大肠杆菌病原体。

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