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首页> 外文期刊>Infection and immunity >Four Clones of Borrelia burgdorferiSensu Stricto Cause Invasive Infection in Humans
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Four Clones of Borrelia burgdorferiSensu Stricto Cause Invasive Infection in Humans

机译：博氏疏螺旋体的四个克隆导致人类侵袭性感染

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Lyme disease begins at the site of a tick bite, producing a primary infection with spread of the organism to secondary sites occurring early in the course of infection. A major outer surface protein expressed by the spirochete early in infection is outer surface protein C (OspC). In Borrelia burgdorferi sensu stricto, OspC is highly variable. Based on sequence divergence, alleles ofospC can be divided into 21 major groups. To assess whether strain differences defined by ospC group are linked to invasiveness and pathogenicity, we compared the frequency distributions of major ospC groups from ticks, from the primary erythema migrans skin lesion, and from secondary sites, principally from blood and spinal fluid. The frequency distribution of ospC groups from ticks is significantly different from that from primary sites, which in turn is significantly different from that from secondary sites. The major groups A, B, I, and K had higher frequencies in the primary sites than in ticks and were the only groups found in secondary sites. We define three categories of major ospC groups: one that is common in ticks but very rarely if ever causes human disease, a second that causes only local infection at the tick bite site, and a third that causes systemic disease. The finding that all systemicB. burgdorferi sensu stricto infections are associated with four ospC groups has importance in the diagnosis, treatment, and prevention of Lyme disease.
机译：莱姆病始于a叮咬部位，引起原发性感染，该生物体扩散到感染过程中较早发生的继发部位。感染初期螺旋体表达的主要外表面蛋白是外表面蛋白C（OspC）。在 sensu stricto中，OspC高度可变。基于序列差异， ospC 等位基因可分为21个主要类别。为了评估由 ospC 组定义的菌株差异是否与侵袭性和致病性有关，我们比较了来自壁虱，原发性红斑移行性皮肤病变的主要 ospC 组的频率分布，以及次要部位，主要是血液和脊髓液。 tick的 ospC 组的频率分布与主要站点的频率分布明显不同，而与次要站点的频率分布则明显不同。主要群体A，B，I和K在主要地点的频率高于壁虱，并且是次要地点中唯一的群体。我们将主要的 ospC 类别定义为三类：一种在tick中很常见，但很少会导致人类疾病;第二种仅在the叮咬部位引起局部感染;第三种是导致全身性感染疾病。发现所有系统性的 B。 burgburgeri sensu stricto感染与四个 ospC 组相关，在莱姆病的诊断，治疗和预防中具有重要意义。

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