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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans.
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The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans.

机译：严格的博氏疏螺旋体基因型在人类中引起传播感染的倾向。

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摘要

Lineages of Borrelia burgdorferi, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (ospC) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of B. burgdorferi present in ticks have a high propensity to disseminate in humans.
机译：引起莱姆病的细菌伯氏疏螺旋体的谱系可以通过在外表面蛋白C（ospC）基因座处的独特等位基因来表征。已经证明以ospC基因型标记的谱系在包括人类在内的不同种类的哺乳动物中具有不同的侵袭性。基因型A，B，I和K有效地传播到人血和脑脊液。在本报告中，我们扩展了从人类血液中分离出的基因型样本，以包括N，H，C，M和D基因型，并根据它们从tick虫传播到人类血液的概率进行排名。我们的结果表明，壁虱中仅存在的B. burgdorferi基因型具有在人中传播的高度倾向。

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