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Changes in Cytokine Levels during Reactivation of Toxoplasma gondii Infection in Lungs

机译：肺弓形虫感染复活过程中细胞因子水平的变化

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We studied cytokine proteins and mRNAs in mice with two forms ofToxoplasma gondii pneumonia resulting from reactivation of infection. In the first form, mice were infected with T. gondii, developed and recovered from systemic disease, and then developed pneumonia 3 weeks later. As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon (IFN-γ), interleukin-2 (IL-2), IL-4, and IL-10 increased in bronchoalveolar lavage (BAL) cells or lung tissue, and the level of IFN-γ protein increased in BAL fluid. The second form of pneumonia occurred as a complication of primary cytomegalovirus (CMV) disease in mice with dormant T. gondii infection. During CMV disease, IL-2 mRNA levels decreased in lung tissue, IL-10 protein levels increased in lung tissue, and IL-10 protein levels increased in BAL fluid. As the mice recovered from CMV disease, T. gondii infection was reactivated in the lungs and was manifested as T. gondii pneumonia. During CMV-inducedT. gondii pneumonia, IFN-γ, IL-2, IL-4, and IL-10 mRNA levels increased in BAL cells or lung tissue, and both IFN-γ and IL-2 protein levels increased in BAL fluid. We concluded that both forms of T. gondii pneumonia are accompanied by increases in both type 1 T-helper and type 2 T-helper cytokine levels in lungs. The mechanism of CMV-induced reactivation ofT. gondii infection in lungs may involve local decreases in IL-2 levels and/or increases in IL-10 levels.
机译：我们研究了由感染再激活引起的两种形式的弓形虫肺炎小鼠的细胞因子蛋白和mRNA。在第一种形式中，小鼠感染了 T。弓形虫，从全身性疾病中发展并恢复，然后在3周后发展为肺炎。随着肺部炎症的发展，支气管肺泡灌洗（BAL）细胞或肺组织中γ干扰素（IFN-γ），白介素2（IL-2），IL-4和IL-10的细胞因子mRNA水平增加，并且该水平BAL液中IFN-γ蛋白的表达增加。肺炎的第二种形式是原发性巨细胞病毒（CMV）疾病在休眠T型小鼠中的并发症。刚地感染。在CMV疾病期间，肺组织中IL-2 mRNA水平降低，肺组织中IL-10蛋白水平升高，而BAL液中IL-10蛋白水平升高。当小鼠从CMV疾病中恢复后， T。刚地弓形虫感染在肺部重新激活，表现为 T。刚地肺炎。在CMV诱导的 T期间。肺炎，BAL细胞或肺组织中的IFN-γ，IL-2，IL-4和IL-10 mRNA水平升高，而BAL液中IFN-γ和IL-2蛋白水平均升高。我们得出结论，两种形式的 T。肺炎伴有肺中1型T辅助细胞和2型T辅助细胞因子水平的升高。 CMV诱导的 T再活化的机制。肺中的弓形虫感染可能涉及局部IL-2水平降低和/或IL-10水平升高。

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