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Immune Responses to Specific Antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the Respiratory Tract

机译：呼吸道对肺炎链球菌和卡他莫拉菌特异性抗原的免疫应答

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Streptococcus pneumoniae and Moraxella catarrhalis are two common respiratory pathogens, colonizing as many as 54 and 72% of children, respectively, by 1 year of age. The immune responses to surface protein A of S. pneumoniae(PspA) and the high-molecular-weight outer membrane protein of M. catarrhalis (UspA) in the sera of various age groups in the general population and in the nasopharynges of 30 children monitored from birth through 1 year of age were evaluated. Immunoglobulin G (IgG) was the dominant serum antibody to PspA and UspA. Whereas the serum antibody response to PspA peaked in childhood, the antibody response to UspA peaked in adulthood. In the first 2 years of life, comparable amounts of IgM and IgG antibodies to both proteins were observed. In older persons, IgG antibodies to both antigens predominated over IgM antibodies. The levels of IgA antibody to these antigens in serum remained low during the first 2 years of life. The levels of IgM antibody to the two antigens in serum exceeded the levels of IgA antibody to the same two antigens throughout life. Although IgA was the dominant antibody to PspA and UspA in airway secretions, it was detected in a minority of the children (3 of 15 for PspA and 0 of 15 for UspA). Even the majority of the children previously colonized with these pathogens lacked antibody to them in their secretions.
机译：肺炎链球菌和卡他莫拉菌是两种常见的呼吸道病原体，到1岁时分别定植在54％和72％的儿童中。在普通人群和监测的30名儿童的鼻咽中，对不同年龄段的血清中肺炎链球菌（PspA）表面蛋白A和粘膜炎莫拉氏菌（UspA）的高分子量外膜蛋白的免疫反应从出生到1岁进行评估。免疫球蛋白G（IgG）是抗PspA和UspA的主要血清抗体。血清对PspA的抗体反应在儿童期达到最高，而对UspA的抗体反应在成年期达到最高。在生命的最初2年中，观察到了相当数量的针对这两种蛋白质的IgM和IgG抗体。在老年人中，针对两种抗原的IgG抗体比IgM抗体占优势。在生命的最初2年中，血清中针对这些抗原的IgA抗体水平仍然很低。在整个生命中，血清中针对两种抗原的IgM抗体水平超过了针对相同两种抗原的IgA抗体水平。尽管IgA是气道分泌物中抗PspA和UspA的主要抗体，但在少数儿童中被检测到（PspA为15分之3，而UspA为15分之0）。甚至以前被这些病原菌定殖的大多数儿童的分泌物中都缺乏针对他们的抗体。

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