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首页> 外文期刊>Infection and immunity >Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits
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Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits

机译：在实验性肺炎球菌性脑膜炎的家兔中，选择素受体阻滞剂岩藻糖苷抑制白细胞进入大脑可降低白细胞介素-1（IL-1）水平，但会增加脑脊液中IL-8水平。

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The polysaccharide fucoidin is a selectin blocker that inhibits leukocyte recruitment into the cerebrospinal fluid (CSF) during experimental pneumococcal meningitis. In the present study, the effect of fucoidin treatment on the release of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), and IL-8 into the CSF was investigated. Rabbits (n = 7) were treated intravenously with 10 mg of fucoidin/kg of body weight every second hour starting 4 h after intracisternal inoculation of ～106 CFU of Streptococcus pneumoniae type 3 (untreated control group, n = 7). CSF samples were obtained every second hour during a 16-h study period. Treatment with fucoidin caused a consistent and significant decrease in CSF IL-1 levels (in picograms per milliliter) between 12 and 16 h (0 versus 170, 0 versus 526, and 60 versus 1,467, respectively;P P > 0.05). In contrast, there was no attenuation in CSF IL-8 levels. Indeed, there was a significant increase in CSF IL-8 levels (in picograms per milliliter) in the fucoidin-treated group at 10 and 12 h (921 versus 574 and 1,397 versus 569, respectively;P < 0.09). In conclusion, our results suggest that blood-derived leukocytes mainly are responsible for the release of IL-1 and to some degree TNF-α into the CSF during pneumococcal meningitis, whereas IL-8 may be produced by local cells within the brain.
机译：多糖岩藻糖苷是一种选择素阻滞剂，可在实验性肺炎球菌性脑膜炎期间抑制白细胞募集到脑脊液（CSF）中。在本研究中，研究了岩藻糖蛋白治疗对促炎细胞因子肿瘤坏死因子α（TNF-α），白介素-1（IL-1）和IL-8释放入脑脊液的影响。在脑池内接种〜106 CFU的3型肺炎链球菌后第4小时，每隔2个小时对兔子（n = 7）进行静脉注射10 mg岩藻依肽/ kg体重（未治疗的对照组，n = 7）。在16小时的研究期内，每隔2小时获取一次CSF样品。用岩藻依定治疗导致CSF IL-1水平持续且显着下降（以每毫升皮克计）在12至16小时之间（分别为0对170、0对526、60对1467; P P> 0.05）。相反，CSF IL-8水平没有减弱。确实，岩藻依丁素治疗组在10和12 h时CSF IL-8水平显着增加（以每毫升皮克计）（分别为921对574和1,397对569; P <0.09）。总之，我们的结果表明，在肺炎球菌性脑膜炎期间，血液来源的白细胞主要负责IL-1的释放，并在一定程度上将TNF-α释放到脑脊液中，而IL-8可能由脑内的局部细胞产生。

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