Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis.

Zysk G; Bruck W; Huitinga I; Fischer FR; Flachsbarth F; van Rooijen N; Nau R

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis.

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Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis.

机译：在实验性肺炎球菌性脑膜炎中，消除血源性巨噬细胞可抑制白介素-1的释放和白细胞进入脑脊液。

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Parameters of inflammation during pneumococcal meningitis were determined in rabbits after monocyte elimination by dichloromethylene diphosphonate (Cl(2)MDP)-containing mannosylated liposomes in comparison with untreated controls. Monocyte depletion reduced the migration of white blood cells into the cerebrospinal fluid (CSF) (medians: 42 versus 2146/mm3 at 18 h, 323 versus 7413/mm3 at 24 h p.i., p < 0.01). CSF IL-1beta concentrations were lower in depleted animals (379 versus 3282 pg/ml, 24 h p.i., p < 0.01), whereas TNF-alpha concentrations were not different. Monocyte-depleted animals lost body temperature during the experiment carried out in anaesthesia (p = 0.01) indicating that macrophages are necessary for thermogenesis during meningitis.

机译：与未经处理的对照相比，测定了兔肺炎球菌性脑膜炎过程中炎症参数，该兔的单核细胞被含二氯亚甲基二膦酸酯（Cl（2）MDP）的甘露糖基化脂质体消除后。单核细胞的消耗减少了白细胞向脑脊液（CSF）的迁移（中位数：在24小时p.i时为42 vs 2146 / mm3，在24 h p.i时为323 vs 7413 / mm3，p <0.01）。耗竭动物中的CSFIL-1β浓度较低（379比3282 pg / ml，24 h p.i.，p <0.01），而TNF-α浓度没有差异。在麻醉下进行的实验中，单核细胞耗尽的动物体温降低（p = 0.01），这表明巨噬细胞是脑膜炎期间生热所必需的。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |1997年第2期|共4页
作者
Zysk G; Bruck W; Huitinga I; Fischer FR; Flachsbarth F; van Rooijen N; Nau R;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Blood Cells; Cerebrospinal Fluid; Interleukin-1; Leukocytes; Macrophages; 血细胞; 脑脊髓液; 白细胞介素1; 白细胞; 巨噬细胞; 脑膜炎; 肺炎球菌;

机译：Blood Cells;Cerebrospinal Fluid;Interleukin-1;Leukocytes;Macrophages;血细胞;脑脊髓液;白细胞介素1;白细胞;巨噬细胞;脑膜炎;肺炎球菌;

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1. Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis. [J] . Zysk G, Bruck W, Huitinga I, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1997,第1a2期

机译：在实验性肺炎球菌性脑膜炎中，消除血源性巨噬细胞可抑制白介素-1的释放和白细胞进入脑脊液。
2. Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits [J] . Christian ?stergaard, Runa Vavia Yieng-Kow, Thomas Benfield, Infection and immunity . 2000,第6期

机译：在实验性肺炎球菌性脑膜炎的家兔中，选择素受体阻滞剂岩藻糖苷抑制白细胞进入大脑可降低白细胞介素-1（IL-1）水平，但会增加脑脊液中IL-8水平。
3. Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis. [J] . Brandt CT, Lundgren JD, Frimodt Moller N, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2005,第1a2期

机译：脑脊液中白细胞积聚的阻断会增加菌血症，并增加实验性肺炎球菌脑膜炎的致死率。
4. Poly(ethylene glycol)-Containing Hydrogels Promote the Release of Primary Granules from Human Blood-Derived Polymorphonuclear Leukocytes [C] . Hannah Caitlin Cohen, Tyler Jacob Lieberthal, W. John Kao Society for Biomaterials annual meeting and exposition . 2014

机译：含聚乙二醇的水凝胶促进人血来源的多形核白细胞释放初级颗粒
5. The study of free-flowing leukocytes in cerebrospinal fluid of normal rhesus monkeys (Macaca mulatta) [D] . Hou, Fang-Yao. 1997

机译：正常恒河猴（猕猴）脑脊液中自由流动白细胞的研究
6. Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits [O] . Christian Østergaard, Runa Vavia Yieng-Kow, Thomas Benfield, 2000

机译：在实验性肺炎球菌性脑膜炎的家兔中选择素受体阻滞剂岩藻糖蛋白抑制白细胞进入脑内可降低白细胞介素1（IL-1）水平但会增加脑脊液中IL-8水平。
7. Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits [O] . Østergaard, Christian, Yieng-Kow, Runa Vavia, Benfield, Thomas, 2000

机译：在实验性肺炎球菌性脑膜炎的家兔中，选择素受体阻滞剂岩藻糖蛋白抑制白细胞进入脑内可降低白细胞介素-1（IL-1）水平，但可增加脑脊液中IL-8水平。
8. Prognostic Value of Cerebrospinal Fluid Protein Content and Leukocyte Count inInfants and Childhood Bacterial Meningitis. (Reannouncement with New Availability Information) [R] . Shaaban, S. Y., Girgis, N. I., Mansour, M. M., 1991

机译：脑脊液蛋白含量和白细胞计数在婴儿和儿童细菌性脑膜炎中的预后价值。（重新公布新的可用性信息）

Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis.

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