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首页> 外文期刊>Infection and immunity >Identification of Novel Genes in Intestinal Tissue That Are Regulated after Infection with an Intestinal Nematode Parasite
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Identification of Novel Genes in Intestinal Tissue That Are Regulated after Infection with an Intestinal Nematode Parasite

机译：肠道线虫寄生虫感染后受调控的肠道组织新基因的鉴定

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摘要

Infection of resistant or susceptible mice with Trichuris muris provokes mesenteric lymph node responses which are polarized towards Th2 or Th1, respectively. These responses are well documented in the literature. In contrast, little is known about the local responses occurring within the infected intestine. Through microarray analyses, we demonstrate that the gene expression profile of infected gut tissue differs according to whether the parasite is expelled or not. Genes differentially regulated postinfection in resistant BALB/c mice include several antimicrobial genes, in particular, intelectin (Itln). In contrast, analyses in AKR mice which ultimately progress to chronic infection provide evidence for a Th1-dominated mucosa with up-regulated expression of genes regulated by gamma interferon. Increases in the expression of genes associated with tryptophan metabolism were also apparent with the coinduction of tryptophanyl tRNA synthetase (Wars) and indoleamine-2,3-dioxygenase (Indo). With the emerging literature on the role of these gene products in the suppression of T-cell responses in vitro and in vivo, their up-regulated expression here may suggest a role for tryptophan metabolism in the parasite survival strategy.
机译：用 Trichuris muris 感染抗性或易感小鼠会引起肠系膜淋巴结反应，这些反应分别朝着Th2或Th1极化。这些反应在文献中有充分记载。相反，对感染的肠道内发生的局部反应知之甚少。通过微阵列分析，我们证明了感染的肠道组织的基因表达谱根据寄生虫是否被驱除而有所不同。抗性BALB / c小鼠中感染后差异调节的基因包括几种抗菌素基因，特别是intelectin（Itln）。相比之下，对最终发展为慢性感染的AKR小鼠的分析提供了Th1为主的粘膜的证据，其γ干扰素调节的基因表达上调。色氨酸tRNA合成酶（Wars）和吲哚胺-2,3-二加氧酶（印度）的共同诱导，与色氨酸代谢相关的基因表达也明显增加。关于这些基因产物在体外和体内抑制T细胞反应中作用的新兴文献，此处它们的上调表达可能暗示色氨酸在寄生虫生存策略中的作用。

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