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首页> 外文期刊>Infection and immunity >Flea-Borne Transmission Model To Evaluate Vaccine Efficacy against Naturally Acquired Bubonic Plague
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Flea-Borne Transmission Model To Evaluate Vaccine Efficacy against Naturally Acquired Bubonic Plague

机译：跳蚤传播模型，以评估疫苗对天然获得性鼠疫的功效。

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A flea-to-mouse transmission model was developed for use in testing new candidate vaccines for the ability to protect against flea-borne plague. The model was used to evaluate a recombinant fusion protein vaccine consisting of the Yersinia pestis F1 and V antigens. After one to three challenges with Y. pestis-infected fleas, 14 of 15 unvaccinated control mice developed plague, with an average septicemia level of 9.2 × 108 Y. pestis CFU/ml. None of 15 vaccinated mice developed the disease after similar challenges, and serological testing indicated that transmitted bacteria were eliminated by the immune system before extensive replication and systemic infection could occur. The transmission and development of disease in control mice correlated with the number of bites by blocked fleas but not with the total number of fleabites. The model provides a means to directly assess the efficacy of new vaccines to prevent naturally acquired bubonic plague and to study events at the vector-host interface that lead to dissemination and disease.
机译：建立了跳蚤-小鼠传播模型，用于测试新的候选疫苗是否具有抵抗跳蚤传播的鼠疫的能力。该模型用于评估由鼠疫耶尔森氏菌F1和V抗原组成的重组融合蛋白疫苗。在对 Y进行1到3个挑战之后。感染鼠疫的跳蚤中，有15只未接种疫苗的对照小鼠中有14只患有鼠疫，平均败血症水平为9.2×10 8 Y。鼠疫 CFU / ml。 15只疫苗接种的小鼠中没有一只在类似的挑战后发展为该病，血清学测试表明，在广泛复制和全身感染发生之前，免疫系统会消除传播的细菌。对照小鼠中疾病的传播和发展与被跳蚤叮咬的次数有关，但与跳蚤的总数无关。该模型提供了一种手段，可以直接评估新疫苗预防天然获得的鼠疫的功效，并可以研究载体-宿主界面上导致传播和疾病的事件。

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