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首页> 外文期刊>Infection and immunity >Matrix Metalloproteinase 9 Plays a Key Role in Lyme Arthritis but Not in Dissemination of Borrelia burgdorferi
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Matrix Metalloproteinase 9 Plays a Key Role in Lyme Arthritis but Not in Dissemination of Borrelia burgdorferi

机译：基质金属蛋白酶9在莱姆关节炎中起关键作用，但在伯氏疏螺旋体的传播中不起作用

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Borrelia burgdorferi, the causative agent of Lyme arthritis, does not produce any exported proteases capable of degrading extracellular matrix despite the fact that it is able to disseminate from a skin insertion site to infect multiple organs. Prior studies have shown that B. burgdorferi induces the host protease, matrix metalloproteinase 9 (MMP-9), and suggested that the induction of MMP-9 may allow the organism to disseminate and produce local tissue destruction. We examined the role of MMP-9 in dissemination of B. burgdorferi and pathogenesis of Lyme arthritis. In a MMP-9?/? mouse model, MMP-9 was not required for the dissemination of the spirochete to distant sites. However, MMP-9?/? exhibited significantly decreased arthritis compared to wild-type mice. The decrease in arthritis was not due to an inability to control infection since the spirochete numbers in the joints were identical. Levels of inflammatory chemokines and cytokines were also similar in MMP-9?/? and wild-type mice. We examined whether decreased inflammation in MMP-9?/? mice may be the result of decreased production of neoattractants by MMP-9-dependent cleavage of collagen. MMP-9 cleavage of type I collagen results in increased monocyte chemoattraction. MMP-9 plays an important role in regulating inflammation in Lyme arthritis, potentially through the cleavage of type I collagen.
机译：莱姆关节炎的病原体，不产生任何能够降解细胞外基质的蛋白酶，尽管它能够从皮肤插入部位传播并感染多个器官。先前的研究表明 B。 burgdorferi 诱导宿主蛋白酶基质金属蛋白酶9（MMP-9），并提示MMP-9的诱导可能使生物传播并产生局部组织破坏。我们研究了MMP-9在 B传播中的作用。 burgdorferi 与莱姆关节炎的发病机制。在MMP-9 ？/？小鼠模型中，不需要将MMP-9用于将螺旋体传播到远处。然而，与野生型小鼠相比，MMP-9 α/β表现出明显降低的关节炎。关节炎的减少不是由于无法控制感染，因为关节中的螺旋体数目相同。 MMP-9 ？/？和野生型小鼠的炎症趋化因子和细胞因子水平也相似。我们检查了MMP-9 ？/？小鼠炎症的降低是否可能是由于MMP-9依赖性胶原蛋白切割引起的新引诱剂产量降低的结果。 I型胶原蛋白的MMP-9裂解导致单核细胞趋化性增加。 MMP-9可能通过裂解I型胶原蛋白在调节莱姆关节炎的炎症中起重要作用。

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