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首页> 外文期刊>Infection and immunity >The Acinetobacter baumannii Biofilm-Associated Protein Plays a Role in Adherence to Human Epithelial Cells
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The Acinetobacter baumannii Biofilm-Associated Protein Plays a Role in Adherence to Human Epithelial Cells

机译：鲍曼不动杆菌生物膜相关蛋白在粘附于人类上皮细胞中发挥作用

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Acinetobacter baumannii is a significant source of nosocomial infections worldwide. This bacterium has the ability to survive and persist on multiple abiotic surfaces in health care facilities, and once a focus has been established, this opportunistic pathogen is difficult to eradicate. This paper demonstrates that the A. baumannii biofilm-associated protein (Bap) is necessary for mature biofilm formation on medically relevant surfaces, including polypropylene, polystyrene, and titanium. Scanning electron microscopy analyses of biofilms show that Bap is required for three-dimensional tower structure and water channel formation. In conjunction with persistence on abiotic surfaces, adherence to eukaryotic cells is an important step in bacterial colonization resulting in infection of the host. We have described Bap as the surface structure involved in adherence of A. baumannii to both normal human bronchial epithelial cells and normal human neonatal keratinocytes. However, Bap is not involved in internalization of the bacterium in these two cell lines. Furthermore, this study shows that the presence of Bap increases the bacterial cell surface hydrophobicity. The results of this study are pertinent, as the data lead to a better understanding of the role of Bap in biofilm formation on medical surfaces and in colonization of the host.
机译：鲍曼不动杆菌是全世界医院感染的重要来源。这种细菌具有在医疗机构中多种非生物表面上生存和持久的能力，一旦确定了焦点，这种机会致病菌就难以根除。本文证明了鲍曼不动杆菌生物膜相关蛋白（Bap）对于在医疗相关表面（包括聚丙烯，聚苯乙烯和钛）上成熟的生物膜形成是必需的。生物膜的扫描电子显微镜分析表明，Bap是三维塔结构和水通道形成所必需的。结合在非生物表面上的持久性，对真核细胞的粘附是细菌定殖导致宿主感染的重要步骤。我们已经将Bap描述为参与鲍曼不动杆菌对正常人支气管上皮细胞和正常人新生儿角质形成细胞的粘附的表面结构。但是，Bap不参与这两个细胞系中细菌的内在化。此外，这项研究表明Bap的存在会增加细菌细胞表面的疏水性。这项研究的结果是相关的，因为数据使人们更好地了解了Bap在医学表面生物膜形成和宿主定植中的作用。

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