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首页> 外文期刊>Infection and immunity >Platelet Activation by Streptococcus pyogenes Leads to Entrapment in Platelet Aggregates, from Which Bacteria Subsequently Escape
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Platelet Activation by Streptococcus pyogenes Leads to Entrapment in Platelet Aggregates, from Which Bacteria Subsequently Escape

机译：化脓性链球菌引起的血小板活化导致血小板聚集体的包埋，随后细菌从中逃逸

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摘要

Platelet activation and aggregation have been reported to occur in response to a number of Gram-positive pathogens. Here, we show that platelet aggregates induced by Streptococcus pyogenes were unstable and that viable bacteria escaped from the aggregates over time. This was not due to differential activation in response to the bacteria compared with physiological activators. All the bacterial isolates induced significant platelet activation, including integrin activation and alpha and dense-granule release, at levels equivalent to those induced by potent physiological platelet activators that induced stable aggregates. The ability to escape the aggregates and to resist the antibacterial effects of platelets was dependent on active protein synthesis by the bacteria within the aggregate. We conclude that S. pyogenes bacteria can temporarily cover themselves with activated platelets, and we propose that this may facilitate survival of the bacteria in the presence of platelets.
机译：据报道，血小板活化和聚集是对许多革兰氏阳性病原体的反应。在这里，我们显示化脓性链球菌诱导的血小板聚集体是不稳定的，并且随着时间的流逝，存活的细菌从聚集体中逸出了。与生理活化剂相比，这不是由于对细菌的差异活化所致。所有细菌分离物均诱导显着的血小板活化，包括整联蛋白活化以及α和致密颗粒释放，其水平与诱导稳定聚集体的强力生理性血小板活化剂诱导的水平相当。逃离聚集体并抵抗血小板的抗菌作用的能力取决于聚集体内细菌的活性蛋白合成。我们得出的结论是，化脓性链球菌可以暂时用活化的血小板覆盖自身，我们建议这可以促进细菌在血小板存在下的存活。

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