目的：观察血小板单核细胞聚集体（PMA）在全麻手术前后及术后3 d的变化，了解检测PMA对全麻手术前后血栓形成预测的意义。方法：流式细胞术检测112例全麻手术患者手术前、手术后及手术后3 d CD62p、CD63、PMA的表达，比较其在3个不同时间的差异。结果：112例患者麻醉诱导前、手术后、术后3 d CD62p的表达分别为（16.74±9.67）%、（22.76±13.89）%、（20.12±9.83）%；CD63的表达分别为（1.35±0.94）%、（2.26±1.75）%、（1.54±0.81）%；PMA的表达分别为（26.86±5.05）%、（31.86±5.31）%、（77.69±5.72）%；手术后CD62p、CD63、PMA，术后3 d CD62p、PMA与麻醉诱导前比较差异均有统计学意义（P<0.05）。结论：PMA可以作为评价血小板活化的指标，并且是一种敏感指标，可能在预测血栓形成中有重要意义。%Objective:To predict the risk of thrombosis in patients with surgery under general anesthesia by monitoring the platelet-monocyte aggregates(PMA)level before the general anesthesia,immediately after the surgery and 3 days after the surgery. Method:Blood samples were collected from 112 cases of patients with surgery under the general anesthesia before the general anesthesia,immediately after the surgery and 3 days after the surgery. The presentation of CD62p,CD63 and PMA were measured and compared. Result:The presentation of CD62p before the general anesthesia,immediately after the surgery and 3 days after the surgery were(16.74±9.67)%,(22.76±13.89)%,(20.12±9.83)%. The presentation of CD63 were(1.35±0.94)%,(2.26±1.75)%,(1.54±0.81)%,and the presentation of PMA were(26.86±5.05)%,(31.86±5.31)%、(77.69±5.72)%;The presentation of CD62p,CD63 and PMA immediately after surgery and the presentation of CD62p,and PMA 3 days after the surgery compared with before the general anesthesia,the differences were all statistically significant(P<0.05). Conclusion:PMA is a sensitive biomarker to evaluate the degree of platelet activation and to predict the possible postoperative thrombosis.
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