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首页> 外文期刊>Infection and immunity >Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae
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Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae

机译：人类的NOD2识别麻风分枝杆菌的结构独特的Muramyl二肽。

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The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of interleukin-32 (IL-32), which leads to the differentiation of monocytes into dendritic cells (DC). NOD2 has been implicated in the pathogenesis of human leprosy, yet it is not clear whether Mycobacterium leprae, which has a distinct MDP structure, can activate this pathway. We investigated the effect of MDP structure on the innate immune response, finding that infection of monocytes with M. leprae induces IL-32 and DC differentiation in a NOD2-dependent manner. The presence of the proximal l-Ala instead of Gly in the common configuration of the peptide side chain of M. leprae did not affect recognition by NOD2 or cytokine production. Furthermore, amidation of the d-Glu residue did not alter NOD2 activation. These data provide experimental evidence that NOD2 recognizes naturally occurring structural variants of MDP.
机译：先天免疫系统通过模式识别受体识别微生物病原体。一种这样的受体，即NOD2，通过识别鼠基二肽（MDP）触发了独特的先天免疫反应网络，包括白介素32（IL-32）的产生，从而导致单核细胞分化为树突状细胞（DC）。 。 NOD2与人类麻风的发病机理有关，但尚不清楚具有独特MDP结构的麻风分枝杆菌是否可以激活该途径。我们调查了MDP结构对先天免疫应答的影响，发现麻风单胞菌感染单核细胞以NOD2依赖性方式诱导IL-32和DC分化。在麻风杆菌的肽侧链的常见构型中，存在近端I-Ala而非Gly，这不会影响NOD2或细胞因子的产生。此外，d-Glu残基的酰胺化不会改变NOD2的活化。这些数据提供了NOD2识别MDP天然存在的结构变异的实验证据。

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