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首页> 外文期刊>International journal of infectious diseases : >Characterization of enterovirus 71 and coxsackievirus A16 isolated in hand, foot, and mouth disease patients in Guangdong, 2010
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Characterization of enterovirus 71 and coxsackievirus A16 isolated in hand, foot, and mouth disease patients in Guangdong, 2010

机译：广东省手足口病患者肠道病毒71型和柯萨奇病毒A16的特征分析，2010年

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Background: Hand, foot, and mouth disease (HFMD) is an acute viral disease caused by human enteroviruses, especially human enterovirus 71 (HEV71) and coxsackievirus A16 (CVA16), and mainly affects infants and young children. After the outbreak in 2008 in Fuyang, China, HFMD was classified as a category C notifiable infectious disease by the Ministry of Health of China. Methods: In this study, we report the epidemiologic and clinical manifestations of HFMD in Guangdong Province, China in 2010, and characterize HEV71 and CVA16 isolated from clinical specimens. Results: Among the 542 HFMD patients, 495 (91.3%) were positive for enterovirus as detected by real-time reverse transcriptase PCR; 243 were positive for HEV71 (49.1%, 243/495) and 114 were positive for CVA16 (23.0%, 114/495). Most of the affected children were aged 5 years or under (93.7%, 508/542). Phylogenetic analyses of VP1 gene sequences showed that the HEV71 isolates belonged to C4a subgenotype, and CVA16 isolates belonged to B1 genotype. Conclusions: Our results demonstrate that HEV71 and CVA16 are the primary causative agents responsible for HFMD in Guangdong Province, and their co-circulation poses a potential risk to public health.
机译：背景：手足口病（HFMD）是由人类肠道病毒，尤其是人类肠道病毒71（HEV71）和柯萨奇病毒A16（CVA16）引起的急性病毒性疾病，主要影响婴幼儿。 2008年在中国富阳爆发后，手足口病被中国卫生部列为C类可报告传染病。方法：本研究报告2010年中国广东省手足口病的流行病学和临床表现，并对从临床标本中分离出的HEV71和CVA16进行鉴定。结果：542例手足口病患者中，实时逆转录PCR检测到肠病毒阳性495例（91.3％）。 243例HEV71阳性（49.1％，243/495），114例CVA16阳性（23.0％，114/495）。大多数受影响的儿童年龄在5岁或以下（93.7％，508/542）。 VP1基因序列的系统进化分析表明，HEV71分离株属于C4a亚型，CVA16分离株属于B1基因型。结论：我们的结果表明，HEV71和CVA16是广东省造成手足口病的主要病原体，它们的共同流通对公众健康构成潜在风险。

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