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首页> 外文期刊>International journal of infectious diseases : >Cerebrospinal fluid features in adults with enteroviral nervous system infection
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Cerebrospinal fluid features in adults with enteroviral nervous system infection

机译：成人肠病毒神经系统感染的脑脊液功能

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Objectives The aim of this study was to investigate the clinical and laboratory features of adults with nervous system infections caused by enteroviruses, with special emphasis on cerebrospinal fluid (CSF). Methods The data of 46 patients who were PCR-positive for enteroviruses in the CSF between 2002 and 2017 were evaluated. Results Meningitis was the most common clinical manifestation (89%), followed by encephalitis (7%) and isolated cranial nerve involvement (4%). Twenty percent of patients reported a sudden onset of severe headache that led to the initial suspected diagnosis of subarachnoid haemorrhage. General signs of infection, such as fever, elevated C-reactive protein, and an elevated white blood cell count, were found in only 61%. Most patients exhibited consistent inflammatory CSF changes, with elevated cell counts (85%) and blood–CSF barrier dysfunction (83%). Patients with normal CSF cell counts were significantly older, less frequently presented with meningitis, and exhibited lower peripheral white blood cell counts. Sequencing revealed species Enterovirus B in all patients, with most sequences related to echovirus 30. Conclusions The absence of CSF pleocytosis, isolated cranial nerve involvement, and only infrequent general signs of infection may impede the diagnosis of enteroviral nervous system infections. A thorough CSF analysis including PCR is essential for a reliable diagnosis.
机译：目的这项研究的目的是调查成人肠病毒引起的神经系统感染的临床和实验室特征，特别是脑脊液（CSF）。方法对2002年至2017年脑脊液中肠病毒PCR阳性的46例患者进行评估。结果脑膜炎是最常见的临床表现（89％），其次是脑炎（7％）和孤立的颅神经受累（4％）。 20％的患者报告严重头痛突然发作，导致最初怀疑诊断为蛛网膜下腔出血。仅61％发现了一般的感染迹象，例如发烧，C反应蛋白升高和白细胞计数升高。大多数患者表现出持续的炎症性脑脊液变化，细胞计数升高（85％）和血液-脑脊液屏障功能障碍（83％）。脑脊液细胞计数正常的患者年龄较大，出现脑膜炎的频率较低，并且外周白细胞计数较低。测序显示所有患者中均存在肠病毒B，大多数序列与回波病毒30有关。结论缺乏脑脊液细胞增多症，孤立的颅神经受累以及仅很少的一般感染迹象可能会妨碍对肠病毒神经系统感染的诊断。彻底的CSF分析（包括PCR）对于可靠的诊断至关重要。

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