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首页> 外文期刊>International Journal of Molecular Sciences >Characterization of Behaviour and Remote Degeneration Following Thalamic Stroke in the Rat
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Characterization of Behaviour and Remote Degeneration Following Thalamic Stroke in the Rat

机译：大鼠丘脑中风后行为和远程变性的特征

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Subcortical ischemic strokes are among the leading causes of cognitive impairment. Selective atrophy of remote brain regions connected to the infarct is thought to contribute to deterioration of cognitive functions. The mechanisms underlying this secondary degenerative process are incompletely understood, but are thought to include inflammation. We induce ischemia by unilateral injection of endothelin-I into the rat dorsomedial thalamic nucleus, which has defined reciprocal connections to the frontal cortex. We use a comprehensive test battery to probe for changes in behaviour, including executive functions. After a four-week recovery period, brain sections are stained with markers for degeneration, microglia, astrocytes and myelin. Degenerative processes are localized within the stroke core and along the full thalamocortical projection, which does not translate into measurable behavioural deficits. Significant microglia recruitment, astrogliosis or myelin loss along the axonal projection or within the frontal cortex cannot be detected. These findings indicate that critical effects of stroke-induced axonal degeneration may only be measurable beyond a threshold of stroke severity and/or follow a different time course. Further investigations are needed to clarify the impact of inflammation accompanying axonal degeneration on delayed remote atrophy after stroke.
机译：皮质下缺血性中风是认知障碍的主要原因。与梗塞相连的偏远大脑区域的选择性萎缩被认为是导致认知功能下降的原因。继发性退化过程的潜在机制尚未完全了解，但被认为包括炎症。我们通过向大鼠背丘脑丘脑核中单侧注射内皮素I诱导缺血，后者已定义了与额叶皮层的相互连接。我们使用全面的测试电池来探究行为的变化，包括执行功能。在四周的恢复期后，用变性，小胶质细胞，星形胶质细胞和髓磷脂的标记物对大脑切片进行染色。退化过程位于中风核心和整个丘脑皮质投影中，这不会转化为可测量的行为缺陷。沿轴突投影或额叶皮质内未发现明显的小胶质细胞募集，星形胶质细胞增生或髓磷脂丢失。这些发现表明，中风诱发的轴突变性的关键影响可能仅在中风严重度的阈值以上和/或遵循不同的时程时才可测量。需要进一步的研究以阐明伴随轴突变性的炎症对中风后延迟远距离萎缩的影响。

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