G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

Jennifer R. Lynch; Jenny Yingzi Wang

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G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

机译：G蛋白与干细胞和癌症中的受体信号传导。

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G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gα q in the maintenance of cancer stem cells in acute myeloid leukemia. This review will discuss how GPCRs and G proteins regulate stem cells with a focus on cancer stem cells, as well as their implications for the development of novel targeted cancer therapies.

机译：G蛋白偶联受体（GPCR）是细胞表面信号蛋白的大型超家族，它们结合细胞外配体并通过异源三聚体G蛋白将信号转导到细胞中。 GPCR是很容易治疗的药物靶标。在各种癌症中已经观察到GPCR和G蛋白的异常表达，并且它们在癌症干细胞中的重要性已经开始被认识。最近，我们报道了G蛋白偶联受体84（GPR84）和G蛋白亚基Gαq在急性髓样白血病的癌症干细胞维持中的重要作用。这篇综述将讨论GPCR和G蛋白如何以癌症干细胞为中心来调控干细胞，以及它们对新型靶向癌症疗法的发展的意义。

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《International Journal of Molecular Sciences》 |2016年第5期|共页
作者
Jennifer R. Lynch; Jenny Yingzi Wang;
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中图分类生物物理学;
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机译：胰岛素受体和G蛋白偶联受体信号系统之间的串扰导致胰腺癌PANC-1细胞Ca（2）+振荡。
2. Comment on "Effects of Atrazine on Estrogen Receptor alpha- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts" [J] . Chevalier Nicolas, Paul-Bellon Rachel, Fenichel Patrick Environmental health perspectives. . 2016,第4期

机译：评论““去津对雌激素受体α和G蛋白偶联受体30介导的癌细胞和癌相关成纤维细胞信号传导和增殖的影响”
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机译：对“关于At去津对雌激素受体α和G蛋白偶联受体30介导的癌细胞和癌症相关成纤维细胞信号传导和增殖的影响的评论”的回应
4. G protein-coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells [C] . Robert M?hle, Adriana C. Drost International Conference and Workshop on Hematopoietic Stem Cells . 2012

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5. Molecular stress signaling in breast epithelial cells: Characterization of the regulation of the breast cancer susceptibility gene 1 (BCRA1) by stress signaling, and, Design of an epidemiological study examining the effect of glucocorticoid receptor genetic variants on breast cancer risk [D] . Antonova, Lilia 2008

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6. Crosstalk between Insulin Receptor and G protein-Coupled Receptor Signaling Systems Leads to Ca2+ Oscillations in Pancreatic Cancer PANC-1 Cells [O] . Steven H. Young, Enrique Rozengurt -1

机译：胰岛素受体和G蛋白偶联受体信号传导系统之间的串扰导致胰腺癌Panc-1细胞中的Ca2 +振荡
7. Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca2+ oscillations in pancreatic cancer PANC-1 cells [O] . Steven H. Young, Enrique Rozengurt 2010

机译：胰岛素受体和G蛋白偶联受体信号传导系统之间的串扰导致胰腺癌Panc-1细胞中的Ca2 +振荡

G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

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