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首页> 外文期刊>International journal of infectious diseases : >Invasive pneumococcal disease among children younger than 5 years of age before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco
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Invasive pneumococcal disease among children younger than 5 years of age before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco

机译：摩洛哥卡萨布兰卡市引入肺炎球菌结合疫苗前后5岁以下儿童的侵袭性肺炎球菌疾病

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Objectives: The purpose of this study was to compare the incidence rate of invasive pneumococcal disease, the rates of antibiotic resistance and serotype distribution among children @?5 years old before and after PCVs introduction in Casablanca, Morocco. Methods: This study was conducted at the Ibn Rochd University Hospital Centre of Casablanca during two periods encompassing pre-and post-implementation of PCVs, respectively from January 2007 to October 2010 and from January 2011 to December 2014. All the non-duplicate invasive S. pneumoniae isolates recovered during the study periods were included. Results: There were 136 cases of IPD, 91 before and 45 after PCVs introduction. The greatest decrease in incidence rate of IPD occurred in children @? 2 years of age declining from 34.6 to 13.5 per 100,000 populations (p<0.0001) before and after vaccination, respectively. The incidence rate of PCV-7, PCV-10 non-PCV-7 and PCV-13 non-PCV-10 serotypes decrease significantly from 18.0 to 4.6, from 5.7 to 1.3 and from 5.7 to 0.8/100,000 population (p<0.001) in the same age, respectively. Conclusion: Shifts in the distribution of IPD serotypes and reductions in the incidence rate of disease suggest an effective reduction of the burden of IPD in children, but continued high quality surveillance is critical to assess the changes in serotype distributions.
机译：目的：本研究的目的是比较摩洛哥卡萨布兰卡市引入PCV前后5岁以下5岁以下儿童的侵袭性肺炎球菌疾病的发病率，抗生素耐药率和血清型分布。方法：本研究在卡萨布兰卡的伊本·罗希德大学医院中心进行，包括PCV的实施前后，分别于2007年1月至2010年10月以及2011年1月至2014年12月进行。所有非重复性侵入性S包括在研究期间回收的肺炎链球菌。结果：IPD 136例，引入PCV之前91例，之后45例。 IPD发病率下降最大的是@@儿童。接种前后2岁的年龄分别从每10万人中的34.6人下降到13.5人（p <0.0001）。 PCV-7，PCV-10非PCV-7和PCV-13非PCV-10血清型的发生率从18.0下降到4.6，从5.7下降到1.3和从5.7下降到0.8 / 100,000人口（p <0.001）在同一年龄。结论：IPD血清型分布的变化和疾病发病率的降低表明儿童IPD负担的有效减轻，但是持续的高质量监测对于评估血清型分布的变化至关重要。

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