...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Molecular Sciences >Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in Rats
【24h】

Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in Rats

机译：甘草提取物对CCl 4 诱导的大鼠氧化损伤的肝保护和抗氧化作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl4)-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl4 at 3 mL/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl4 intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-α levels induced by CCl4 intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury.
机译：欧亚甘草已被用于中草药治疗各种疾病。欧亚甘草具有脱毒，抗氧化和抗感染的生物学功能。在这项研究中，我们评估了甘草水提取物（LE）对四氯化碳（CCl 4 ）诱导的大鼠肝损伤的抗肝毒性作用。组织学和血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP）活性增加以及血清总蛋白（TP），白蛋白（Alb）和球蛋白（ G）是通过以3 mL / kg bw的剂量施用CCl 4 诱导的（在花生油中为1：1）。甘草提取物显着抑制CCl 4 中毒引起的AST，ALP和ALT活性升高以及TP，Alb和G水平降低。它还增强了肝脏超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GSH-Px），谷胱甘肽还原酶（GR），谷胱甘肽S-转移酶（GST）活性和谷胱甘肽（GSH）含量，降低了丙二醛（MDA）水平。甘草提取物仍能明显逆转CCl 4 中毒引起的肝脏羟脯氨酸和血清TNF-α水平的升高。这项研究的数据支持甘草提取物对肝氧化损伤的化学预防潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号