Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents

Carmen Limban; Mariana Carmen Chifiriuc

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Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents

机译：含氟和三氟甲基取代基的新型二苯并肟酮肟的抗菌活性

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In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF₃) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF₃ and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.

机译：在本文中，我们介绍了一些新合成的带有肟基部分的二苯并[b，e] oxepin衍生物以及氟（F）和三氟甲基（CF _{3 ）取代基的抗菌活性。通过元素分析，NMR和FTIR光谱评估了新化合物的化学结构和纯度。通过定性和定量分析，筛选了新化合物对革兰氏阳性和革兰氏阴性菌株的抗菌活性。我们的结果表明，CF _{3 和F二取代化合物可被认为是进一步开发新型抗菌药物的基础。}}

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《International Journal of Molecular Sciences》 |2011年第10期|共13页
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Carmen Limban; Mariana Carmen Chifiriuc;
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6. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents [O] . Carmen Limban, Mariana Carmen Chifiriuc 2011

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7. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents [O] . Limban, Carmen, Chifiriuc, Mariana Carmen 2011

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Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents

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