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首页> 外文期刊>International Journal of Molecular Sciences >Involvement of Host Non-Coding RNAs in the Pathogenesis of the Influenza Virus
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Involvement of Host Non-Coding RNAs in the Pathogenesis of the Influenza Virus

机译：宿主非编码RNA参与流感病毒的发病机理。

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Non-coding RNAs (ncRNAs) are a new type of regulators that play important roles in various cellular processes, including cell growth, differentiation, survival, and apoptosis. ncRNAs, including small non-coding RNAs (e.g., microRNAs, small interfering RNAs) and long non-coding RNAs (lncRNAs), are pervasively transcribed in human and mammalian cells. Recently, it has been recognized that these ncRNAs are critically implicated in the virus–host interaction as key regulators of transcription or post-transcription during viral infection. Influenza A virus (IAV) is still a major threat to human health. Hundreds of ncRNAs are differentially expressed in response to infection with IAV, such as infection by pandemic H1N1 and highly pathogenic avian strains. There is increasing evidence demonstrating functional involvement of these regulatory microRNAs, vault RNAs (vtRNAs) and lncRNAs in pathogenesis of influenza virus, including a variety of host immune responses. For example, it has been shown that ncRNAs regulate activation of pattern recognition receptor (PRR)-associated signaling and transcription factors (nuclear factor κ-light-chain-enhancer of activated B cells, NF-κB), as well as production of interferons (IFNs) and cytokines, and expression of critical IFN-stimulated genes (ISGs). The vital functions of IAV-regulated ncRNAs either to against defend viral invasion or to promote progeny viron production are summarized in this review. In addition, we also highlight the potentials of ncRNAs as therapeutic targets and diagnostic biomarkers.
机译：非编码RNA（ncRNA）是一种新型调节剂，在各种细胞过程（包括细胞生长，分化，存活和凋亡）中起着重要作用。 ncRNA，包括小的非编码RNA（例如，microRNA，小的干扰RNA）和长的非编码RNA（lncRNA），已在人类和哺乳动物细胞中普遍转录。最近，人们已经认识到这些ncRNA在病毒与宿主的相互作用中是病毒感染过程中转录或转录后转录的关键调控因子。甲型流感病毒（IAV）仍然是人类健康的主要威胁。响应IAV感染（例如大流行H1N1和高致病性禽流感病毒感染），数百种ncRNA差异表达。越来越多的证据表明，这些调节性microRNA，穹顶RNA（vtRNA）和lncRNA在流感病毒的发病机理中包括各种宿主免疫反应均涉及功能。例如，已显示ncRNA调节与模式识别受体（PRR）相关的信号和转录因子（活化的B细胞的核因子κ-轻链增强子，NF-κB）的激活，以及干扰素的产生（IFN）和细胞因子，以及关键IFN刺激基因（ISG）的表达。这篇综述总结了IAV调控的ncRNA的重要功能，即防御病毒入侵或促进子代病毒的产生。此外，我们还强调了ncRNA作为治疗靶标和诊断生物标志物的潜力。

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