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首页> 外文期刊>Molecular medicine reports >Involvement of dysregulated coding and long non-coding RNAs in the pathogenesis of strabismus
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Involvement of dysregulated coding and long non-coding RNAs in the pathogenesis of strabismus

机译：在斜视的发病机制中涉及失调的编码和长期非编码RNA

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Strabismus is a common ocular disorder in children and may result in exterior abnormalities and impaired visual functions. However, the detailed pathogenesis of strabismus unclear. The present study assessed the comprehensive analyses on the roles of RNAs in the development of strabismus. The public datasets of strabismus and the corresponding control tissues were downloaded from the Gene Expression Omnibus (GEO). Reannotations of the dysregulated coding and long non-coding RNAs (lncRNAs) and functional enrichments of the differently expressed genes (DEGs) were conducted. A total of 790 DEGs were screened (648 upregulated and 142 downregulated) in the present study. Among the DEGs, a total of 32 differently expressed lncRNAs were detected (14 upregulated and 18 downregulated). When the Gene Ontology (GO) enrichment was considered, it was identified that a total of 143 GO terms (82 for biological process, 31 for cellular component and 30 for molecular function) were identified. Among all the 57 detected Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, the phagosome pathway, which was labeled as hsa004145, demonstrated the most bioinformatics importance. However, most lncRNAs, except LINC01279 and LOC643733, indicated 3 target mRNAs and were not suitable for advanced bioinformatics analyses. Bioinformatics analyses demonstrated that there was a GO term for each lncRNA (proteinaceous extracellular for LINC01279 and cell surface for LOC643733). In conclusion, a set of coding RNA as well as lncRNAs differentially expressed in strabismus EOM samples were indicated. Notably, the present findings important information for advanced pathogenesis research and biomarkers detection.
机译：斜视是小儿常见的眼部疾病，并可能导致外部异常和受损的视觉功能。但是，目前还不清楚斜视的发病细节。本研究评估了RNA的斜视的发展中的作用的综合分析。斜视的公共数据集和相应的控制组织从基因表达综合（GEO）下载。的失调编码和长的非编码RNA（lncRNAs）和差异表达的基因（DEGS）的功能性富集的Reannotations进行的。总共790度的视角进行了筛选在本研究中（648上调和下调142）。其中DEGS，共有32个差异表达的lncRNAs检测（14上调和下调18）。当基因本体论（GO）富集被认为是，它鉴别出共143个GO术语（82，用于生物处理中，31为细胞组分和30，用于分子功能）进行了鉴定。在所有57的检测基因和基因组（KEGG）通路京都百科全书，吞噬途径，这被打成hsa004145，展示了生物信息学最重要的。然而，大多数lncRNAs，除了LINC01279和LOC643733，指示＆LT; 3个靶mRNA和不适合用于高级的生物信息学分析。生物信息学分析表明，有针对每个lncRNA（对于LINC01279蛋白质的细胞外和LOC643733细胞表面）一个GO术语。总之，一组编码的RNA以及斜视EOM样品中差异表达的lncRNAs被指示。值得注意的是，目前的研究结果对先进发病机制的研究和生物标志物检测的重要信息。

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