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首页> 外文期刊>International Journal of Molecular Sciences >Time, Concentration, and pH-Dependent Transport and Uptake of Anthocyanins in a Human Gastric Epithelial (NCI-N87) Cell Line
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Time, Concentration, and pH-Dependent Transport and Uptake of Anthocyanins in a Human Gastric Epithelial (NCI-N87) Cell Line

机译：花青素在人胃上皮细胞（NCI-N87）细胞中的时间，浓度和pH依赖性转运和摄取

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摘要

Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anthocyanins absorption may occur in the stomach, in which the acidic pH favors anthocyanin stability. A gastric epithelial cell line (NCI-N87) has been used to study the behavior of anthocyanins at a pH range of 3.0–7.4. This work examines the effects of time (0–3 h), concentration (50–1500 μM), and pH (3.0, 5.0, 7.4) on the transport and uptake of anthocyanins using NCI-N87 cells. Anthocyanins were transported from the apical to basolateral side of NCI-N87 cells in time and dose dependent manners. Over the treatment time of 3 h the rate of transport increased, especially with higher anthocyanin concentrations. The non-linear rate of transport may suggest an active mechanism for the transport of anthocyanins across the NCI-N87 monolayer. At apical pH 3.0, higher anthocyanin transport was observed compared to pH 5.0 and 7.4. Reduced transport of anthocyanins was found to occur at apical pH 5.0.
机译：花青素是水溶性植物色素中最大的一类，是人类饮食中的共同组成部分。它们可能具有许多潜在的健康益处，包括抗氧化剂，抗炎，抗癌和心脏保护活性。但是，花色素苷的代谢尚不十分清楚。研究表明，花青素的吸收可能在胃中发生，其中酸性pH值有利于花青素的稳定性。胃上皮细胞系（NCI-N87）已用于研究在3.0-7.4的pH范围内花色苷的行为。这项工作检查了时间（0–3小时），浓度（50–1500μM）和pH（3.0、5.0、7.4）对使用NCI-N87细胞转运和摄取花色苷的影响。花青素以时间和剂量依赖性方式从NCI-N87细胞的顶侧转运到基底外侧。在3小时的治疗时间内，运输速度增加，尤其是花青素浓度较高时。非线性传输速率可能表明花色素苷跨NCI-N87单层传输的积极机制。在顶端pH 3.0下，与pH 5.0和7.4相比，观察到更高的花色素苷转运。发现花青素的运输减少在顶端pH 5.0下发生。

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