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首页> 外文期刊>International Journal of Molecular Sciences >Emerging Role of Eukaryote Ribosomes in Translational Control
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Emerging Role of Eukaryote Ribosomes in Translational Control

机译：真核生物核糖体在翻译控制中的新兴作用。

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Translation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of “specialized ribosomes”, which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today.
机译：翻译是调节基因表达的最后步骤之一。核糖体在其在mRNA解码和蛋白质合成中的作用一直是翻译的效应子。已经广泛描述了许多解释翻译调控的机制。但是，直到最近才出现核糖体本身可以促进这种调节的现象。确实，尽管众所周知细胞的翻译效率与核糖体丰度有关，但最近的研究表明核糖体的组成可以改变特定mRNA的翻译。有证据表明，根据状态，环境，发育或病理状况，细胞会产生不同的核糖体群体，其核糖体蛋白和/或RNA组成也不同。这些观察结果提出了“特殊核糖体”的概念，该概念提出独特的核糖体组成决定了该核糖体的翻译活性。本篇综述将介绍技术进步如何参与了这一概念的产生，以及当今文献在多大程度上维持了这一概念。

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