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首页> 外文期刊>Investigative ophthalmology & visual science >Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Photopic Contrast Sensitivity in Mice
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Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Photopic Contrast Sensitivity in Mice

机译：慢性和急性眼压升高对小鼠暗视和明暗对比敏感度的影响

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Purpose: To compare the impact of intraocular pressure (IOP) elevation on scotopic and photopic contrast sensitivity in mice. Methods: We chronically elevated the IOP of wild-type mice via injection of polystyrene beads or acutely via injection of highly cohesive sodium hyaluronate. Some eyes with chronically elevated IOP were treated with either topical brimonidine tartrate 0.1% or brinzolamide 1%. Scotopic and photopic contrast sensitivity was assessed at peak spatiotemporal frequencies at multiple time points, with an established optokinetic technique. Retinal ganglion cell (RGC) counts were determined with an antibody to class III beta-tubulin. Correlations among IOP level, RGC count, and scotopic or photopic contrast sensitivity were performed. Results: Six weeks of IOP elevation caused a generalized reduction of photopic contrast sensitivity and a preferential reduction of scotopic contrast sensitivity at peak spatiotemporal frequencies. The administration of brinzolamide but not brimonidine caused a significant reduction in cumulative IOP, whereas brimonidine, but not brinzolamide, prevented RGC loss. Both brimonidine and brinzolamide prevented contrast sensitivity loss, but brimonidine did so at earlier time points and across a wider range of lighting conditions. Following either chronic or acute IOP elevation, scotopic contrast sensitivity was impacted most prominently by IOP level and not by RGC count, while photopic contrast sensitivity was impacted by a combination of factors. Conclusions: It is possible that scotopic-specific retinal circuitry is altered preferentially by IOP elevation, and that changes in scotopic contrast sensitivity will assist with glaucoma detection. Brimonidine appears to prevent RGC loss via an IOP-independent mechanism.
机译：目的：比较眼内压（IOP）升高对小鼠暗视和明视对比敏感度的影响。方法：我们通过注射聚苯乙烯珠或长期注射高黏性透明质酸钠来长期提高野生型小鼠的IOP。使用0.1％酒石酸溴莫尼定或1％烟酸苯甲酰胺治疗局部IOP长期升高的眼睛。利用既定的光动力学技术，在多个时间点的峰值时空频率上评估了暗视和明视对比敏感度。视网膜神经节细胞（RGC）计数是通过抗III类β-微管蛋白的抗体确定的。进行了眼压水平，RGC计数和暗视或明暗对比敏感度之间的相关性。结果：眼压升高六周会导致明视对比敏感度普遍降低，并且在峰值时空频率下暗视对比敏感度会优先降低。施用溴苯甲酰胺而不是溴莫尼定引起累积IOP的显着降低，而溴莫尼定而不是溴苯甲酰胺阻止了RGC的损失。溴莫尼定和溴苯甲酰胺都可以防止对比度敏感度下降，但是溴莫尼定在更早的时间点和更广泛的照明条件下都可以防止这种情况。慢性或急性IOP升高后，暗视对比敏感度受IOP水平而非RGC计数影响最大，而明视对比敏感度受多种因素影响。结论：IOP升高可能会优先改变暗室特定的视网膜电路，暗室对比敏感度的变化将有助于青光眼的检测。溴莫尼定似乎通过独立于IOP的机制防止RGC丢失。

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