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Adhesins as Targets for Vaccine Development

机译：粘附素作为疫苗开发的目标

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Blocking the primary stages of infection, namely bacterial attachment to host cell receptors and colonization of the mucosal surface, may be the most effective strategy to prevent bacterial infections. Bacterial attachment usually involves an interaction between a bacterial surface protein called an adhesin and the host cell receptor. Recent preclinical vaccine studies with the FimH adhesin (derived from uropathogenic Escherichia coli) have confirmed that antibodies elicited against an adhesin can impede colonization, block infection, and prevent disease. The studies indicate that prophylactic vaccination with adhesins can block bacterial infections. With recent advances in the identification, characterization, and isolation of other adhesins, similar approaches are being explored to prevent infections, from otitis media and dental caries to pneumonia and sepsis.
机译：阻断感染的主要阶段，即细菌附着于宿主细胞受体和粘膜表面定殖，可能是预防细菌感染的最有效策略。细菌附着通常涉及称为粘附素的细菌表面蛋白与宿主细胞受体之间的相互作用。 FimH粘附素（源自尿路致病性大肠埃希氏大肠杆菌）最近的临床前疫苗研究已证实，针对粘附素引发的抗体可以阻止定植，阻止感染并预防疾病。研究表明，粘附素的预防接种可以阻断细菌感染。随着其他粘附素的鉴定，表征和分离的最新进展，人们正在探索类似的方法来预防感染，从中耳炎和龋齿到肺炎和败血症。

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