...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Venezuelan Equine Encephalitis Virus Transmission and Effect on Pathogenesis
【24h】

Venezuelan Equine Encephalitis Virus Transmission and Effect on Pathogenesis

机译：委内瑞拉马脑炎病毒传播及其发病机理

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Quantifying the dose of an arbovirus transmitted bymosquitoes is essential for designing pathogenesis studiessimulating natural infection of vertebrates. Titration of sali-va collected in vitro from infected mosquitoes may notaccurately estimate titers transmitted during blood feeding,and infection by needle injection may affect vertebratepathogenesis. We compared the amount of Venezuelanequine encephalitis virus collected from the saliva of Aedestaeniorhynchus to the amount injected into a mouse duringblood feeding. Less virus was transmitted by mosquitoes invivo (geometric mean 11 PFU) than was found for compa-rable times of salivation in vitro (mean saliva titer 74 PFU).We also observed slightly lower early and late viremia titersin mice that were needle injected with 8 PFU, which repre-sents the low end of the in vivo transmission range. No dif-ferences in survival were detected, regardless of the doseor infection route
机译：量化蚊子传播的虫媒病毒的剂量对于设计模拟脊椎动物自然感染的发病机理研究至关重要。从感染的蚊子中体外收集的唾液的滴定可能无法准确地估计进食过程中传播的滴度，而通过针头注射感染可能会影响脊椎动物的发病机理。我们将采自Aedestaeniorhynchus唾液中的委内瑞拉马蜂脑炎病毒的量与采血期间注入小鼠的量进行了比较。蚊子体内传播的病毒（几何平均数为11 PFU）少于在体外唾液可比的传播时间（平均唾液滴度为74 PFU）。我们还观察到针头注射8的早期和晚期病毒血症滴度略低PFU，代表体内传播范围的低端。无论剂量或感染途径如何，均未发现生存差异

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号