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首页> 外文期刊>Emerging Infectious Diseases >Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada
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Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada

机译：加拿大鸡肉和人类肠小肠沙门氏菌海德堡中的头孢噻呋耐药性

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The Canadian Integrated Program for Antimicrobial Re-sistance Surveillance describes a strong correlation (r = 0.9, p<0.0001) between ceftiofur-resistant Salmonella enterica serovar Heidelberg isolated from retail chicken and inci-dence of ceftiofur-resistant Salmonella serovar Heidelberg infections in humans across Canada. In Québec, changes of ceftiofur resistance in chicken Salmonella Heidelberg and Escherichia coli isolates appear related to changing levels of ceftiofur use in hatcheries during the study period, from highest to lowest levels before and after a voluntary with-drawal, to increasing levels after reintroduction of use (62% to 7% to 20%, and 34% to 6% to 19%, respectively). These events provide evidence that ceftiofur use in chickens results in extended-spectrum cephalosporin resistance in bacteria from chicken and humans. To ensure the contin-ued effectiveness of extended-spectrum cephalosporins for treating serious infections in humans, multidisciplinary ef-forts are needed to scrutinize and, where appropriate, limit use of ceftiofur in chicken production in Canada
机译：加拿大抗菌素耐药性综合计划描述了从零售鸡中分离出的头孢噻呋耐药肠炎沙门氏菌海德堡与人类头孢噻呋耐药沙门氏菌海德堡感染的发病率之间存在很强的相关性（r = 0.9，p <0.0001）加拿大。在魁北克省，鸡沙门氏菌海德堡和大肠杆菌分离株的头孢噻呋耐药性变化与研究期间孵化场中头孢噻呋使用水平的变化有关，从自愿退出之前和之后的最高水平到最低水平，再到重新引入使用（分别为62％至7％至20％和34％至6％至19％）。这些事件提供了证据，证明在鸡中使用头孢噻呋会导致鸡和人类细菌的广谱头孢菌素耐药。为了确保广谱头孢菌素在治疗人类严重感染方面具有持续的有效性，需要多学科的努力来仔细研究并酌情限制在加拿大鸡肉生产中使用头孢噻呋

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