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Novel Hepatitis E Virus in Ferrets, the Netherlands

机译：荷兰雪貂中的新型戊型肝炎病毒

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To the Editor: Hepatitis E virus (HEV), a member of the family Hepeviridae and the genus Hepevirus, is transmitted by the fecal–oral route and causes liver in. ammation, which leads to mortality rates of ≈20% in pregnant woman (1,2). Human hepatitis E is a major disease not only in developing countries but also in industrialized countries, and identifi cation of animal strains of HEV in pigs and deer and its zoonotic potential has raised considerable public health concerns (1,3). Recent reports suggest that other animals such as rats, mongooses, chickens, rabbits, and trout also may harbor HEVs (1–5). The genomes of these viruses are ≈6.6 kb–7.2 kb and encode 3 open reading frames (ORFs) . anked by a capped 5′ end and a poly A tail at the 3′ end (1,3). We used random PCR amplifi cation and high-throughput sequencing technology to investigate HEV sequences in ferrets (Mustela putorius) from the Netherlands
机译：致编辑：戊型肝炎病毒科和戊型肝炎病毒属的成员之一戊型肝炎病毒（HEV）通过粪便-口腔途径传播并引起肝脏变性，导致孕妇的死亡率约为20％（ 1,2）。人戊型肝炎不仅在发展中国家而且在工业化国家都是主要疾病，对猪和鹿中戊型肝炎病毒动物株的识别及其人畜共患病潜力引起了相当大的公共卫生关注（1,3）。最近的报告表明，其他动物，例如大鼠，猫鼬，鸡，兔和鳟鱼，也可能藏有HEV（1-5）。这些病毒的基因组约为6.6 kb–7.2 kb，编码3个开放阅读框（ORF）。由带盖的5'端和3'端的聚A尾（1,3）支撑。我们使用随机PCR扩增和高通量测序技术来研究荷兰雪貂（Mustela putorius）的HEV序列

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