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首页> 外文期刊>Molecular and Cellular Biology >Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein.
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Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein.

机译：小鼠大脑CD4转录本仅编码该蛋白质COOH末端的一半。

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The T-cell surface glycoprotein CD4 is thought to function as a receptor for class II major histocompatibility complex molecules. Human CD4 is also the lymphoid cell receptor for human immunodeficiency virus, the causative agent of acquired immune deficiency syndrome. The observed infection of the central nervous system in acquired immune deficiency syndrome patients raises the possibility that CD4 is also present in nerve tissue and that a cell surface receptor for class II major histocompatibility complex antigens could play a role in central nervous system function. This possibility is reinforced by the detection of unique CD4-related transcripts in mouse and human brain tissue. In this study, the structure of the mouse brain CD4 transcript was determined. It is identical to the last two-thirds of the CD4 message and is capable of encoding a 217-residue protein that would consist of a truncated, 154-residue, cell surface region, together with the complete CD4 transmembrane and cytoplasmic regions. It would not include an amino-terminal hydrophobic leader peptide.
机译：T细胞表面糖蛋白CD4被认为是II类主要组织相容性复合物分子的受体。人CD4还是人免疫缺陷病毒（获得性免疫缺陷综合症的病因）的淋巴样细胞受体。在获得性免疫缺陷综合症患者中观察到的中枢神经系统感染增加了CD4也存在于神经组织中以及II类主要组织相容性复合抗原的细胞表面受体可能在中枢神经系统功能中起作用的可能性。通过在小鼠和人脑组织中检测独特的CD4相关转录本，可以增强这种可能性。在这项研究中，确定了小鼠大脑CD4转录本的结构。它与CD4信息的后三分之二相同，并且能够编码217个残基的蛋白质，该蛋白质由一个截短的154个残基的细胞表面区域以及完整的CD4跨膜和胞质区域组成。它不包括氨基末端的疏水前导肽。

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