A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

J Rogers; N Fasel; R Wall

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A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

机译：一种新的RNA，其中5'端通过在免疫球蛋白重链分泌的mRNA的poly（A）位点切割而产生。

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We describe processed RNA species generated by cleavage at poly(A) sites in the immunoglobulin mu and gamma 2b heavy-chain transcription units. These "amputated transcripts" began at the first or "secreted" poly(A) site and ended at the second or "membrane" poly(A) site. Although they were polyadenylated and apparently spliced, they were largely restricted to the nucleus. Their existence confirms that the heavy-chain mRNAs are derived from RNA cleavage at alternative poly(A) sites.

机译：我们描述了在免疫球蛋白mu和gamma 2b重链转录单位中的poly（A）切割位点产生的已加工RNA种类。这些“截断的转录本”始于第一个或“分泌的” poly（A）位点，结束于第二个或“膜” poly（A）位点。尽管它们被聚腺苷酸化并且显然是剪接的，但是它们在很大程度上限于核。它们的存在证实了重链mRNAs是从RNA切割的poly（A）位点衍生而来的。

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《Molecular and Cellular Biology》 |1986年第12期|共4页
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J Rogers; N Fasel; R Wall;
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中图分类细胞生物学;
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1. U1A Inhibits Cleavage at the Immunoglobulin M Heavy-Chain Secretory Poly(A) Site by Binding between the Two Downstream GU-Rich Regions [J] . Catherine Phillips, Niseema Pachikara, Samuel I. Gunderson Molecular and Cellular Biology . 2004,第14期

机译：U1A通过绑定两个下游富GU区之间的结合，抑制免疫球蛋白M重链分泌性Poly（A）的切割。
2. Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA. [J] . K J Nelson, J Haimovich, R P Perry Molecular and Cellular Biology . 1983,第7期

机译：免疫球蛋白重链基因座的生产性和无菌转录本的表征：微米和muS mRNA的加工。
3. Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions [J] . Yang Q, Sarnow P Nucleic Acids Research . 1997,第14期

机译：内部核糖体进入位点在免疫球蛋白重链结合蛋白（BiP）mRNA的5'非编码区的位置：特定RNA蛋白质相互作用的证据
4. A cassette ribonuclease:site selective cleavage of RNA by a ribonuclease S-bearing RNA-recognition segment [C] . Shiroh Futaki, Michihiro Araki, Tatsuto kiwada, the International Peptide Symposium . 2001

机译：盒式核糖核酸酶：通过核糖核酸酶S轴承RNA识别段的RNA的位点选择性切割
5. The detection of ribonuclease cleavage sites in host and viral RNAs during viral infections [D] . Cooper, Daphne A. 2015

机译：病毒感染期间宿主和病毒RNA中核糖核酸酶切割位点的检测
6. A novel RNA in which the 5 end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA. [O] . J Rogers, N Fasel, R Wall 1986

机译：一种新的RNA其中5端是通过切割免疫球蛋白重链分泌的mRNA的poly（A）位点产生的。
7. A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA. [O] . Rogers, J, Fasel, N, Wall, R 1986

机译：一种新的RNA，其中5'端是通过切割免疫球蛋白重链分泌的mRNA的poly（A）位点产生的。

A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

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