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首页> 外文期刊>Molecular and Cellular Biology >Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
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Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.

机译：酿酒酵母HIS4位点的核酸酶超敏位点与减数分裂重组热点活性之间的关系。

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摘要

Meiotic double-strand DNA breaks (DSBs), the lesions that initiate meiotic recombination at the HIS4 recombination hot spot, occur in a region upstream of the coding sequence associated with multiple DNase I-hypersensitive sites. Mutations in transcription factors that lead to loss of the DSBs result in the loss of some but not all DNase I-hypersensitive sites in the upstream region. A meiosis-specific change in chromatin structure is detected in strains with the wild-type hot spot but not in strains with alterations that elevate or reduce hot spot activity. The position and intensity of micrococcal nuclease-hypersensitive sites correlate poorly with the sites of DSB formation.
机译：减数分裂双链DNA断裂（DSB）是在HIS4重组热点处引发减数分裂重组的损伤，发生在与多个DNase I超敏感位点相关的编码序列的上游区域。导致DSB丢失的转录因子突变导致上游区域中某些但不是全部DNase I超敏感位点丢失。在具有野生型热点的菌株中检测到染色质结构的减数分裂特异性变化，但在具有升高或降低热点活性的变化的菌株中未检测到。微球菌核酸酶超敏感位点的位置和强度与DSB形成位点的相关性很差。

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