The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

E B Jakobovits; U Schlokat; J L Vannice; R Derynck; A D Levinson

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The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

机译：人转化生长因子α启动子在没有TATA序列的情况下指导从单个位点的转录起始。

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Transforming growth factor alpha (TGF-alpha) is a transformation-responsive mitogenic polypeptide that is expressed in the brain, epithelial cells, and activated macrophages. We isolated and characterized the TGF-alpha promoter and localized the 5' end of the TGF-alpha transcript to a unique position. Surprisingly, no apparent TATA box was present in the promoter sequence, suggesting that transcription from mammalian genes can initiate at unique and specific positions from promoters lacking this sequence motif.

机译：转化生长因子α（TGF-alpha）是一种在大脑，上皮细胞和活化的巨噬细胞中表达的转化反应性有丝分裂多肽。我们分离并表征了TGF-α启动子，并将TGF-α转录本的5'端定位在一个独特的位置。令人惊讶地，在启动子序列中不存在明显的TATA盒，这表明来自哺乳动物基因的转录可以在缺乏该序列基序的启动子的独特且特定的位置开始。

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《Molecular and Cellular Biology》 |1988年第12期|共6页
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E B Jakobovits; U Schlokat; J L Vannice; R Derynck; A D Levinson;
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中图分类细胞生物学;
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1. The binding site for the liver-specific transcription factor Tf-LF1 and the TATA box of the human transferrin gene promoter are the only elements necessary to direct liver-specific transcription in vitro [J] . Daniel Mendelzon, Fran?ois Boissier, Mario M. Zakin Nucleic acids research . 1990,第19期

机译：肝脏特异性转录因子Tf-LF1的结合位点和人转铁蛋白基因启动子的TATA框是在体外指导肝脏特异性转录的唯一要素
2. The binding site for the liver-specific transcription factor Tf-LF1 and the TATA box of the human transferrin gene promoter are the only elements necessary to direct liver-specific transcription in vitro [J] . Daniel Mendelzon, Fran?ois Boissier, Mario M. Zakin Nucleic acids research . 1990,第19期

机译：肝脏特异性转录因子Tf-LF1的结合位点和人转铁蛋白基因启动子的TATA框是在体外指导肝脏特异性转录的唯一要素
3. p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53. [J] . T H Shin, A J Paterson, J E Kudlow Molecular and Cellular Biology . 1995,第9期

机译：p53刺激人类转化生长因子α启动子的转录：p53的潜在生长刺激作用。
4. Identifying Transcription Factor Binding Sites in Promoters of Human Genes [C] . Wei Shi, Wanlei Zhou International Multi-Conference on Computing in the Global Information Technology . 2006

机译：鉴定人基因启动子中的转录因子结合位点
5. Two stories of human transcription regulation: Bidirectional promoters and the multiple transcription start sites of FOXP2 [D] . Schroeder, Diane Irene 2008

机译：人类转录调控的两个故事：双向启动子和FOXP2的多个转录起始位点
6. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. [O] . E B Jakobovits, U Schlokat, J L Vannice, 1988

机译：人转化生长因子α启动子在不存在TATA序列的情况下指导从单个位点的转录起始。
7. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. [O] . Jakobovits, E B, Schlokat, U, Vannice, J L, 1988

机译：人转化生长因子α启动子在不存在TATA序列的情况下指导从单个位点的转录起始。

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

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