A cysteine-rich nuclear protein activates yeast metallothionein gene transcription.

M S Szczypka; D J Thiele

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A cysteine-rich nuclear protein activates yeast metallothionein gene transcription.

机译：富含半胱氨酸的核蛋白激活酵母金属硫蛋白基因转录。

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The ACE1 gene of the yeast Saccharomyces cerevisiae is required for copper-inducible transcription of the metallothionein gene (CUP1). The sequence of the cloned ACE1 gene predicted an open reading frame for translation of a 225-amino-acid polypeptide. This polypeptide was characterized by an amino-terminal half rich in cysteine residues and positively charged amino acids. The arrangement of many of the 12 cysteines in the configuration Cys-X-Cys or Cys-X-X-Cys suggested that the ACE1 protein may bind metal ions. The carboxyl-terminal half of the ACE1 protein was devoid of cysteines but was highly acidic in nature. The ability of a bifunctional ACE1-beta-galactosidase fusion protein to accumulate in yeast cell nuclei was consistent with the possibility that ACE1 plays a direct role in the regulation of copper-inducible transcription of the yeast metallothionein gene.

机译：铜质金属硫蛋白基因（CUP1）的铜诱导转录需要酵母酿酒酵母的ACE1基因。克隆的ACE1基因的序列预测了一个开放阅读框，可翻译225个氨基酸的多肽。该多肽的特征在于富含半胱氨酸残基和带正电荷的氨基酸的氨基末端一半。 Cys-X-Cys或Cys-X-X-Cys构型中的12个半胱氨酸中的许多半胱氨酸的排列表明ACE1蛋白可以结合金属离子。 ACE1蛋白的羧基末端一半没有半胱氨酸，但实际上是高度酸性的。双功能ACE1-β-半乳糖苷酶融合蛋白在酵母细胞核中积累的能力与ACE1在铜诱导的金属硫蛋白基因的转录诱导调控中起直接作用的可能性是一致的。

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《Molecular and Cellular Biology》 |1989年第2期|共9页
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M S Szczypka; D J Thiele;
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中图分类细胞生物学;
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1. Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABFI protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. [J] . P K Brindle, J P Holland, C E Willett, Molecular and Cellular Biology . 1990,第9期

机译：多种因素结合酵母烯醇化酶基因ENO1和ENO2的上游激活位点：ABFI蛋白像阻遏物激活蛋白RAP1一样，结合可调节转录抑制或激活的顺式作用序列。
2. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. [J] . C Buchman, P Skroch, J Welch, Molecular and Cellular Biology . 1989,第9期

机译：CUP2基因产物是酵母金属硫蛋白表达的调节剂，是一种铜激活的DNA结合蛋白。
3. Superinduction of metallothionein I by inhibition of protein synthesis: role of a labile repressor in MTF-1 mediated gene transcription. [J] . Bi Y, Lin GX, Millecchia L, Journal of biochemical and molecular toxicology . 2006,第2期

机译：通过抑制蛋白质合成超诱导金属硫蛋白I：不稳定阻遏物在MTF-1介导的基因转录中的作用。
4. Interactome of the Nuclear Basket Proteins of the Yeast Nuclear Pore Complex [C] . Mario Niepel, Kelly Molloy, Ileana M. Cristea, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：酵母核孔隙络合物核篮蛋白的互动组
5. Spatial regulation of Cdc42 by its GTPase-activating proteins Rga1 and Bem2 in budding yeast Saccharomyces cerevisiae [D] . Tong, Zongtian 2008

机译：Cdc42的GTPase激活蛋白Rga1和Bem2在发芽酵母中的空间调控
6. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. [O] . M S Szczypka, D J Thiele 1989

机译：富含半胱氨酸的核蛋白激活酵母金属硫蛋白基因转录。
7. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. [O] . Szczypka, M S, Thiele, D J 1989

机译：富含半胱氨酸的核蛋白激活酵母金属硫蛋白基因转录。

A cysteine-rich nuclear protein activates yeast metallothionein gene transcription.

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