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首页> 外文期刊>Molecular and Cellular Biology >Connections between the Ras-cyclic AMP pathway and G1 cyclin expression in the budding yeast Saccharomyces cerevisiae.
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Connections between the Ras-cyclic AMP pathway and G1 cyclin expression in the budding yeast Saccharomyces cerevisiae.

机译：Ras环AMP途径和芽孢酵母酿酒酵母中G1细胞周期蛋白表达之间的联系。

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摘要

We have identified two processes in the G1 phase of the Saccharomyces cerevisiae cell cycle that are required before nutritionally arrested cells are able to return to proliferative growth. The first process requires protein synthesis and is associated with increased expression of the G1 cyclin gene CLN3. This process requires nutrients but is independent of Ras and cyclic AMP (cAMP). The second process requires cAMP. This second process is rapid, is independent of protein synthesis, and produces a rapid induction of START-specific transcripts, including CLN1 and CLN2. The ability of a nutritionally arrested cell to respond to cAMP is dependent on completion of the first process, and this is delayed in cells carrying a CLN3 deletion. Mating pheromone blocks the cAMP response but does not alter the process upstream of Ras-cAMP. These results suggest a model linking the Ras-cAMP pathway with regulation of G1 cyclin expression.
机译：我们已经确定了酿酒酵母细胞周期的G1期中的两个过程，这些过程在营养停止的细胞能够恢复增生之前是必需的。第一个过程需要蛋白质合成，并与G1细胞周期蛋白基因CLN3的表达增加有关。此过程需要营养，但与Ras和循环AMP（cAMP）无关。第二个过程需要cAMP。第二个过程是快速的，与蛋白质合成无关，并且可以快速诱导START特异性转录物，包括CLN1和CLN2。营养停滞的细胞对cAMP的反应能力取决于第一个过程的完成，而在携带CLN3缺失的细胞中，这被延迟了。信息素交配会阻断cAMP反应，但不会改变Ras-cAMP上游的过程。这些结果表明，模型将Ras-cAMP途径与G1细胞周期蛋白表达的调节联系起来。

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