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首页> 外文期刊>Molecular and Cellular Biology >Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins.
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Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins.

机译：雌激素对禽肝的长期影响：雌激素诱导的核，激素结合蛋白表达的转换。

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The stimulation of chicks or embryos with estrogen results in transient, hepatic expression of the vitellogenin gene, as well as long-term, propagatable alterations in the rapidity with which the gene can be reactivated. We examined the possibility that nuclear, type II estrogen-binding sites are involved in this long-term change in response characteristics. We demonstrate that the primary induction kinetics of type II sites in embryos and chicks correlated with the expression of the vitellogenin gene and that once their induction was triggered by estrogen, they accumulated, were propagated, and persisted for months after withdrawal of the hormone. We also show that their accumulation in the embryo was accompanied by prolonged expression of both the vitellogenin and very low-density apolipoprotein II genes, in the absence of elevated levels of type I receptor, and that the type II sites, like the classical receptor, appear to be preferentially associated with active or potentially active chromatin. Finally, we describe a regulatory mechanism, tested by computer modelling, that simulated the behavioral characteristics of these nuclear estrogen-binding sites and which may explain their role in mediating the long-term effects of estrogen.
机译：用雌激素刺激雏鸡或胚胎会导致卵黄蛋白原基因的瞬时肝表达，以及使该基因重新激活的速度发生长期的，可传播的变化。我们研究了II型雌激素结合位点参与这种反应特征的长期变化的可能性。我们证明，胚胎和雏鸡中II型位点的主要诱导动力学与卵黄蛋白原基因的表达相关，并且一旦它们的诱导被雌激素触发，它们就会积累，繁殖并在撤离激素后持续数月。我们还显示了它们在胚胎中的积累伴随着卵黄蛋白原和极低密度载脂蛋白II基因的延长表达，而没有升高的I型受体水平，并且II型位点（如经典受体）似乎优先与活性或潜在活性染色质相关。最后，我们描述了一种通过计算机建模测试的调节机制，该机制模拟了这些核雌激素结合位点的行为特征，并可能解释了它们在介导雌激素长期作用中的作用。

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