Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3).

H R Kim; N S Yew; W Ansorge; H Voss; C Schwager; B Vennstr?m; M Zenke; J D Engel

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Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3).

机译：从单个基因组基因座转录两个不同的mRNA，它们编码鸡的红细胞阴离子转运蛋白（条带3）。

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The chicken erythrocyte anion transport protein (band 3 of the erythrocyte cytoskeleton) is a central component taking part in two widely divergent functions of erythroid cells; it is a primary determinant of cytoskeletal architecture and responsible for electroneutral Cl-/HCO3- exchange across the plasma membrane. To analyze interesting aspects of the developmental regulation of this gene, we have cloned the cDNA and genomic counterparts of the erythroid-specific anion transport protein. We show that a single genetic locus for band 3 encodes two different erythroid cell-specific mRNAs, with different translational initiation sites, which predict polypeptides of sizes very close to those observed in vivo. In vitro translation and immune precipitation of synthetic mRNA derived from one putative fully encoding cDNA clone demonstrate that this clone gives rise to a protein which is identical in size and antigenicity to bona fide chicken erythroid band 3.

机译：鸡的红细胞阴离子转运蛋白（红细胞骨架的3带）是参与类红细胞两种广泛不同功能的重要组成部分。它是细胞骨架结构的主要决定因素，并负责跨质膜的电子中性Cl- / HCO3-交换。为了分析该基因的发育调控的有趣方面，我们已经克隆了类胡萝卜素特异性阴离子转运蛋白的cDNA和基因组对应物。我们显示带3的单个遗传基因座编码两个不同的类红细胞特异性mRNA，具有不同的翻译起始位点，这些位点预测多肽的大小与体内观察到的非常接近。源自一个推定的完全编码cDNA克隆的合成mRNA的体外翻译和免疫沉淀表明，该克隆产生了一种蛋白质，其大小和抗原性与真正的鸡红系带3相同。

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《Molecular and Cellular Biology》 |1988年第10期|共9页
作者
H R Kim; N S Yew; W Ansorge; H Voss; C Schwager; B Vennstr?m; M Zenke; J D Engel;
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中图分类细胞生物学;
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1. Distribution of high mobility group proteins 1/2,E and 14/17 and linker histones H1 and H5 on transcribed and non-transcribed regions of chicken erythrocyte chromatin [J] . Alexander V. Belyavsky, Andrei D. Mirzabekov, Konstantin L. Brodolin, Nucleic acids research . 1991,第4期

机译：高迁移率族蛋白1/2，E和14/17以及接头组蛋白H1和H5在鸡红细胞染色质的转录和非转录区域上的分布
2. Distribution of high mobility group proteins 1/2,E and 14/17 and linker histones H1 and H5 on transcribed and non-transcribed regions of chicken erythrocyte chromatin [J] . Alexander V. Belyavsky, Andrei D. Mirzabekov, Konstantin L. Brodolin, Nucleic acids research . 1991,第4期

机译：高迁移率族蛋白1/2，E和14/17以及接头组蛋白H1和H5在鸡红细胞染色质的转录和非转录区域上的分布
3. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. [J] . Iida A, Saito S, Sekine A, Journal of human genetics . 2001,第11期

机译：在编码三个有机阴离子转运蛋白，三个有机阴离子转运多肽和三个NADH：泛醌氧化还原酶黄素蛋白的基因中的258个单核苷酸多态性（SNP）目录。
4. Differences in myosin heavy chain mRNA expression levels among chicken muscles reflect differences in protein polymerization by transglutaminase [C] . Ahhmed A.M., Tomisaka Y., Muguruma M., ICoMST 2011;International conference of meat science and technology . 2012

机译：鸡肌肉中肌球蛋白重链mRNA表达水平的差异反映了转谷氨酰胺酶在蛋白质聚合中的差异
5. Structural and functional studies of human band 3, the anion transport protein of the erythrocyte membrane. [D] . Casey, Joseph Roman. 1993

机译：人类带3（红细胞膜的阴离子转运蛋白）的结构和功能研究。
6. Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3). [O] . H R Kim, N S Yew, W Ansorge, 1988

机译：从单个基因组基因座转录两个不同的mRNA它们编码鸡的红细胞阴离子转运蛋白（条带3）。
7. Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3). [O] . Kim, H R, Yew, N S, Ansorge, W, 1988

机译：从单个基因组基因座转录两个不同的mRNA，它们编码鸡的红细胞阴离子转运蛋白（条带3）。

Two different mRNAs are transcribed from a single genomic locus encoding the chicken erythrocyte anion transport proteins (band 3).

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