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首页> 外文期刊>Molecular and Cellular Biology >Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells.
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Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells.

机译:尼日尔预处理的中国仓鼠卵巢细胞中蓖麻毒素的增强内化作用。

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摘要

Biochemical and electron microscopic autoradiographic studies with [125I] ricin have revealed that nigericin-pretreated Chinese hamster ovary cells are more efficient than untreated cells in the internalization of the toxin into the cells. These results suggest that the enhanced rate of internalization of ricin in nigericin-pretreated cells may account for the enhancement of cytotoxicity of ricin in Chinese hamster ovary cells by nigericin.
机译:用[125I]蓖麻毒蛋白进行的生化和电子显微镜放射自显影研究表明,尼日尔预处理的中国仓鼠卵巢细胞在将毒素内化到细胞中比未处理的细胞更有效。这些结果表明,尼日尔预处理细胞中蓖麻毒蛋白内在化速率的提高可能解释了尼日尔霉素对中国仓鼠卵巢细胞蓖麻毒蛋白的细胞毒性的增强作用。

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